ArticleAdvances in radiation oncology2026
Intravascular Radiation Delays Recurrence of Recalcitrant Coronary In-Stent Restenosis.
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
12 authors.
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Abstract
Purpose: Intravascular brachytherapy (IVBT) has a well-proven activity against coronary restenosis of a native vessel or a single bare metal stent. However, its effectiveness for multiple recurrent same-vessel in-stent restenoses (ISRs) is unproven. The objective of this study was to determine if IVBT prolongs the ISR-free interval in recalcitrant lesions. Methods and Materials: ISR-free intervals before and after IVBT for individual patients were compared. T1 was the ISR-free interval prior to IVBT, and T2 was the ISR-free interval after IVBT. Accrual was sought from patients with a prior ISR-free interval of less than 2 years. Standard radiation techniques were used, with doses of 18, 23, or 34 Gy prescribed at 2 mm from the radiation source. ISR-free intervals before (T1) and after IVBT (T2) were compared. Results: Twenty-six vessels in 19 patients were studied. ISR-free intervals prior to IVBT ranged from 25 to 317 days (median, 96 days) compared with ISR-free intervals after IVBT that ranged from 30 to 612 days (median, 350 days; Conclusion: The results support the use of IVBT to prolong the ISR-free interval in recalcitrant ISRs.
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