Evidence map›Paper›PMID 42746302›Full record

ReviewLancet regional health. Americas2026

Medical, interventional, and surgical management of rheumatic heart disease.

Sheila L Klassen, Luiz G Passaglia, Vicente R Silva, Bhagawan Koirala, Kunjang Sherpa, Marcelo Martins, Lucas Lodi-Junqueira, Jacob Dal-Bianco, Maria Carmo P Nunes, Robert A Levine and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet regional health. Americas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sheila L KlassenDivision of Cardiovascular Medicine and Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, USA.
Luiz G PassagliaHospital das Clinicas and School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Vicente R SilvaHospital das Clinicas and School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Bhagawan KoiralaKathmandu Institute of Child Health, Kathmandu, Nepal.
Kunjang SherpaNational Academy of Medical Sciences, Kathmandu, Nepal.
Marcelo MartinsHospital das Clinicas and School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Lucas Lodi-JunqueiraHospital das Clinicas and School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Jacob Dal-BiancoEchocardiography Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Maria Carmo P NunesHospital das Clinicas and School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Robert A LevineEchocardiography Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Leducq PRIMA Network: Preventing Rheumatic Injury biomarker Allianceg
Leducq PRIMA Network: Preventing Rheumatic Injury biomarker Alliance

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatic heart disease (RHD) is a lifelong chronic condition with complex pathogenesis and major management challenges in regions where it is endemic. Therapeutic difficulties stem from the need for prolonged medical treatment and lifelong surgical planning in a predominantly young population. Gaps in our understanding of optimal medical and surgical treatment strategies persist, in part because clinically apparent RHD has become uncommon in high-income countries, where most therapeutic innovations historically originate, limiting research investment in this population. This review summarizes established and emerging aspects of the medical management of RHD, its major complications, and available surgical and transcatheter interventions with a focus on the mitral valve. Ongoing research continues to expand the evidence base for RHD care, but parallel efforts to strengthen health systems are essential to ensure effective delivery of available therapies. Sustained global collaboration, research partnerships, and policy initiatives are critical to improving outcomes for individuals living with RHD worldwide.

Indexed as

Acute rheumatic feverBalloon mitral valvuloplastyLow-income countriesMitral valve surgeryRheumatic heart disease

Identifiers

PMID42746302
PMCPMC13575801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.