Evidence map›Paper›PMID 42746212›Full record

ArticleOpen forum infectious diseases2026

Comorbidities and Patient Outcomes in Carbapenem-Resistant Gram-negative Bacterial Infections.

Jean-Francois Jabbour, Yixuan Li, Angelique E Boutzoukas, Blake Hanson, Yohei Doi, Eric Cober, Erica Herc, Lauren Komarow, Jose M Munita, Martin E Stryjewski and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jean-Francois JabbourDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-0214-8290
Yixuan LiThe Biostatistics Center, George Washington University, Bethesda, Maryland, USA.
Angelique E BoutzoukasDepartment of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-9477-1492
Blake HansonCenter for Infectious Diseases and Microbial Genomics, UTHealth, McGovern School of Medicine at Houston, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-2949-7818
Yohei DoiCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-9620-2525
Eric CoberDepartment of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-3243-9299
Erica HercDivision of Infectious Diseases, Department of Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Lauren KomarowThe Biostatistics Center, George Washington University, Bethesda, Maryland, USA.
Jose M MunitaMillennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R) and Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.ORCID https://orcid.org/0000-0002-7870-1056
Martin E StryjewskiDivision of Infectious Diseases, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina.
Cesar A AriasDivision of Infectious Diseases, Houston Methodist Hospital and Houston Methodist Research Institute, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-9054-9774
David L PatersonADVANCE-ID, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.ORCID https://orcid.org/0000-0003-2079-4437
Michael J SatlinDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0003-4711-5334
Vance G FowlerDivision of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Robert A BonomoDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-3299-894X
David van DuinDivision of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0003-4784-3227
Antibacterial Resistance Leadership Group
Antibacterial Resistance Leadership Group

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

In an international cohort of hospitalized patients included in the Multi-Drug-Resistant Organism Network with carbapenem-resistant Gram-negative infections, increased age-adjusted Charlson Comorbidity Index scores were associated with increased mortality particularly in those with respiratory and less so in those with bloodstream infections. Cirrhosis, diabetes, and peripheral vascular disease were important contributors.

Indexed as

antimicrobial resistancecomorbiditiesGram-negative infections

Identifiers

PMID42746212
PMCPMC13576414

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.