Evidence map›Paper›PMID 42746090›Full record

ArticleEJHaem2026

Somatic Mitochondrial-Nuclear DNA Transfer in Lymphoproliferative Disorders.

James Peter Stewart, Nikos Darzentas, Miguel Alcoceba, Maria Eugenia Sarasquete, Anthony V Moorman, Mark Catherwood, Binaya Regmi, Christiane Pott, Anton W Langerak, David Gonzalez

Abstract read
In one paragraph

Article in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James Peter StewartJohnston Centre for Cancer Research Queens University Belfast Belfast UK.
Nikos DarzentasDepartment of Hematology University Hospital Schleswig-Holstein Kiel Germany.
Miguel AlcocebaCancer Research Center-IBMCC (USAL-CSIC) University Hospital of Salamanca (HUS/IBSAL), CIBERONC Salamanca Spain.
Maria Eugenia SarasqueteCancer Research Center-IBMCC (USAL-CSIC) University Hospital of Salamanca (HUS/IBSAL), CIBERONC Salamanca Spain.
Anthony V MoormanTranslational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK.
Mark CatherwoodBelfast City Hospital Belfast UK.
Binaya RegmiDepartment of Hematology University Hospital Schleswig-Holstein Kiel Germany.
Christiane PottDepartment of Hematology University Hospital Schleswig-Holstein Kiel Germany.
Anton W LangerakDepartment of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands.
David GonzalezJohnston Centre for Cancer Research Queens University Belfast Belfast UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Somatic mitochondrial-nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours. Methods: EuroClonality-NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for SMNT-associated structural variants. Results: Five malignancies (0.66%) harboured SMNTs, predominantly involving Conclusion: SMNTs are rare but recurrent events in lymphoid malignancies and may represent stable clonal markers for minimal residual disease monitoring. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

Identifiers

PMID42746090
PMCPMC13575760

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.