Evidence map›Paper›PMID 42746058›Full record

ArticleMedComm2026

Cooccurrence of Homologous Recombination Deficiency and Mismatch Repair Deficiency in Colorectal Cancer.

Xu Zhang, Hao Xu, Kailai Wang, Wangxiong Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xu ZhangDepartment of Ultrasound in Medicine The Second Affiliated Hospital of Zhejiang University School of Medicine Zhejiang University Hangzhou Zhejiang China.
Hao XuDepartment of Clinical Laboratory Central Hospital of Jinhua City Jinhua Zhejiang China.
Kailai WangCancer Institute (Key Laboratory of Cancer Prevention and Intervention National Ministry of Education) The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China.
Wangxiong HuCancer Institute (Key Laboratory of Cancer Prevention and Intervention National Ministry of Education) The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China.ORCID https://orcid.org/0000-0002-2287-9242

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homologous recombination deficiency (HRD) in colorectal cancer (CRC) remains largely unexplored. In contrast, mismatch repair deficiency (dMMR) occurs in ∼15% of patients with CRC. Although HRD and dMMR have historically been regarded as mutually exclusive, emerging evidence suggests that this mutual exclusivity may not be absolute. Here, we conducted a retrospective cohort study utilizing genomic and transcriptomic data to define HRD status in a Chinese dMMR CRC cohort (

Indexed as

colorectal cancergene expression signaturehomologous recombination deficiencymachine learningmismatch repair deficiency

Identifiers

PMID42746058
PMCPMC13575765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.