ArticleFrontiers in immunology2026
Identification of Wnt/β-catenin- and immune-related genes in hepatic ischemia-reperfusion injury using bulk transcriptomics, single-cell RNA sequencing, and a murine model.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Hepatic ischemia-reperfusion injury (HIRI) is a major complication following liver transplantation (LT), contributing to graft dysfunction and rejection. The roles of the Wnt/β-catenin signaling pathway and immune responses in LT-related HIRI remain incompletely elucidated. This study aimed to screen key genes associated with Wnt/β-catenin signaling scores and immune regulation in HIRI after LT. Methods: Three LT-related transcriptomic datasets (GSE151648, GSE12720, and GSE189539) were analyzed. Wnt/β-catenin pathway-related genes (WRGs) and immune-related genes (IRGs) were integrated. Weighted gene co-expression network analysis (WGCNA), differential expression analysis, and machine learning algorithms (Boruta and LASSO) were employed to identify hub genes. CIBERSORT was used to perform deconvolution analysis of bulk transcriptomic data and estimate the relative proportions of 22 immune cell types. Regulatory networks of key gene expression, including TF-mRNA and lncRNA-miRNA-mRNA networks, were constructed. Preliminary expression-level validation was performed in a non-transplant murine HIRI model using qPCR, Western blot, histological analysis, and serological assessment. Results: Four pivotal genes- Conclusion: This study identifies
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