ArticleFrontiers in neurology2026
Lower admission reverse shock index multiplied by Glasgow coma scale score is associated with early hematoma expansion in spontaneous intracerebral hemorrhage.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Early hematoma expansion (HE) contributes to neurological deterioration after spontaneous intracerebral hemorrhage (sICH), but simple bedside tools for early risk stratification remain limited. This study examined the association between the reverse shock index multiplied by Glasgow Coma Scale score (rSIG) and early HE and evaluated its predictive performance. Methods: Consecutive adults with sICH admitted to a single center between July 2016 and June 2026 were retrospectively included. rSIG was calculated as Glasgow Coma Scale score × systolic blood pressure/heart rate using first admission measurements. HE was defined as an absolute hematoma-volume increase >6 mL or a relative increase >33% on follow-up non-contrast computed tomography within 8 h. Associations were assessed using hierarchical logistic regression, restricted cubic splines, quartile analysis, bootstrap resampling, and 1:2 matched sensitivity analysis. Results: Of 2,450 patients screened, 2,035 were included, and 156 (7.7%) developed early HE. Each 5-point decrease in rSIG was independently associated with higher odds of HE in the fully adjusted model (adjusted odds ratio, 1.783; 95% confidence interval, 1.560-2.038; Conclusion: Lower admission rSIG was independently and nonlinearly associated with early HE after sICH. rSIG may provide a rapid bedside aid for early risk stratification and complement imaging assessment, although prospective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.