Evidence map›Paper›PMID 42745763›Full record

ArticleFrontiers in veterinary science2026

Nucleotide sequence variations, gene expression profiles, and host biomarkers associated with ovine mange caused by

Manal A Babaker, Mohamed Marzok, Ahmed El Sayed, Tahani M I Al-Hazani, Ahmed Ateya, Fatimah S Alharbi, Elham Mohammed Alzahrani, Rowa K Zarah, Adel I Almubarak, Hussein Babiker and 6 more

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Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Manal A BabakerDepartment of Chemistry, Faculty of Science, Majmaah University, Al Majmaah, Saudi Arabia.
Mohamed MarzokDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Ahmed El SayedDepartment of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC), Mataryia, Cairo, Egypt.
Tahani M I Al-HazaniBiology Department, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Ahmed AteyaDepartment of Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Fatimah S AlharbiDepartment of Biology, College of Sciences, Taif University, Taif, Saudi Arabia.
Elham Mohammed AlzahraniDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Rowa K ZarahDepartment of Biology, College of Sciences, Taif University, Taif, Saudi Arabia.
Adel I AlmubarakDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Hussein BabikerDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Turke ShawafDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Mohammed Al-RasheedDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Rasha Yassin ElkhidrDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Zakriya Al MohamadDepartment of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Omar A Al-JabrDepartment of Microbiology, College of Veterinary Medicine, King Faisal University, Al-Asha, Saudi Arabia.
Bassem ElmishmishyParasitological Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Ovine mange is a highly contagious skin disease that causes substantial economic losses. This study assessed the prevalence, SNPs, gene expression, serum APPs, and immune and antioxidant markers to elucidate the immunological and oxidative mechanisms of mange in Barki sheep. Methods: A total of 320 adult Barki ewes were enrolled in the study, comprising 80 clinically affected animals and 240 apparently healthy controls. Blood samples were collected from all animals for the determination of acute-phase proteins, immunological and antioxidant biomarkers, and gene expression analyses of CARD9, CLEC7A, TNFAIP3, IL33, SESN2, ATF4, HSPA1A, and SLC7A11. Only clinically affected sheep underwent parasitological confirmation by microscopic examination of deep skin scrapings collected from active skin lesions to identify mange mites. Results: Microscopic examination confirmed mange in 25% (80/320) of the ewes, with Conclusion: Ovine mange is associated with distinct molecular, immunological, and oxidative stress responses that reflect the host's reaction to mite infestation. To our knowledge, this is the first study to integrate transcriptional profiling with SNP characterization of

Indexed as

antioxidantAPPsimmunitymolecular diagnosticsPsoroptes spp.Sarcoptes spp.sheep

Identifiers

PMID42745763
PMCPMC13574585

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