Evidence map›Paper›PMID 42745462›Full record

ArticleBioMed research international2026

Epidemiological and Clinical Risk Factors for Breast Cancer-Related Lymphedema: A Case-Control Study From Hamadan, Western Iran.

Soulmaz Rahbar, Hojjat Radinmehr, Mohammad Reza Asadi, Tayebeh Roghani, Azade Tabatabaei, Abdolazim Sedighi Pashaki, Erfan Ayubi

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Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Soulmaz RahbarDepartment of Physiotherapy, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran, umsha.ac.ir.ORCID https://orcid.org/0000-0001-9561-0677
Hojjat RadinmehrDepartment of Physiotherapy, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran, umsha.ac.ir.ORCID https://orcid.org/0000-0003-0007-431X
Mohammad Reza AsadiDepartment of Physiotherapy, School of Rehabilitation Sciences, Hamadan University of Medical Sciences, Hamadan, Iran, umsha.ac.ir.ORCID https://orcid.org/0000-0002-8487-5909
Tayebeh RoghaniDepartment of Physical Therapy, School of Rehabilitation Sciences, Isfahan University of Medical Sciences, Isfahan, Iran, mui.ac.ir.ORCID https://orcid.org/0000-0003-2030-5373
Azade TabatabaeiDepartment of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran, tums.ac.ir.ORCID https://orcid.org/0009-0008-7867-3869
Abdolazim Sedighi PashakiCancer Research Center, Institute of Cancer, Hamadan University of Medical Sciences, Hamadan, Iran, umsha.ac.ir.ORCID https://orcid.org/0000-0003-2210-5797
Erfan AyubiCancer Research Center, Institute of Cancer, Hamadan University of Medical Sciences, Hamadan, Iran, umsha.ac.ir.ORCID https://orcid.org/0000-0002-8829-9304

Funding

Hamadan University of Medical Sciences 140303292698
6 · The paper itself

Abstract

backgroundBreast cancer-related lymphedema (BCRL) is one of main issues following treatments in patients with breast cancer (BC). The current study is aimed at evaluating epidemiological and clinical risk factors for BCRL in female patients with BC.

methodsIn a case-control study design from October 2024 to March 2025, female BC patients with and without BCRL were recruited from the Lymphedema Physiotherapy Clinic and the Cancer Therapeutic and Diagnosis Imaging Center in Hamadan, Western Iran. Patient, tumor, and treatment characteristics were gathered via interview and reviewing medical and pathology records.

resultsOverall, 230 patients (127 cases and 103 controls) were included. The multivariable analysis revealed several potential risk factors for BCRL: older age at diagnosis (odds ratio [OR] = 1.05; 95% confidence interval [CI], 1.00, 1.10), urban residency (4.76; 1.20, 20.00), axillary lymph node dissection number of 6-9 compared to ≤ 5 (2.54; 0.99, 6.49), pathology grade of 2 (7.11; 1.47, 34.27) and 3 (6.53; 1.32, 32.32) compared to Grade 1, mastectomy versus lumpectomy (2.86; 1.23, 6.67), receiving chemotherapy (9.55; 1.23, 73.95), and positive progesterone receptor (PR) status (2.56; 1.16, 5.55).

conclusionThe combination of patient, tumor, and treatment characteristics may be associated with BCRL, highlighting the close monitoring of high-risk patients (older age, high-grade tumors, mastectomy, and PR-positive) in Western Iran.

Indexed as

Breast Cancer LymphedemaBreast NeoplasmsAdultAgedCase-Control StudiesFemaleHumansIranLymph Node ExcisionMastectomyMiddle AgedRisk Factorsbreast cancer-related lymphedemacase control studyIranrisk factors

Identifiers

PMID42745462
PMCPMC13578934

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