ArticlemAbs2026
A framework for evaluating unexpected reactions in antibody-drug conjugates during clinical development: a case study of a promiscuous payload.
Article in mAbs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Antibody-drug conjugates (ADCs) are complex biotherapeutic molecules, comprising an antibody moiety and a small molecule linker-drug. The product quality of an ADC is controlled through monitoring of critical quality attributes to ensure safety and efficacy. During development, unexpected changes may occur in the product quality of an ADC, for example under stress or physiological conditions. This should prompt a systematic evaluation to determine the cause and impact on product quality. A structured approach for such an evaluation is not well established. Here, a strategy for the detection, identification, and assessment of unexpected reactions in an ADC during clinical development is presented encompassing physicochemical and functional analytical characterization, mechanistic confirmation, and evaluation of the relevance
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