ArticleThe international journal of behavioral nutrition and physical activity2026
Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis.
Michael J Stein, Claas Lendt, Fabian Bamberg, Janett Barbaresko, Hansjörg Baurecht, Klaus Berger, Patricia Bohmann, Julian Brummer, Christoph Buck, Beate Fischer and 28 more
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In one paragraphArticle in The international journal of behavioral nutrition and physical activity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Michael J SteinDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, 93053, Germany. michael.stein@helmholtz-munich.de.ORCID http://orcid.org/0000-0002-1120-1751 Fabian BambergDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.ORCID http://orcid.org/0000-0002-7460-3942 Janett BarbareskoInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, Düsseldorf, 40225, Germany.ORCID http://orcid.org/0000-0003-0855-2769 Julian BrummerDivision of Physical Activity, Cancer Prevention and Survivorship, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg, 69120, Germany.ORCID http://orcid.org/0000-0001-9022-5497 Beate FischerDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, 93053, Germany.
Heinz FreislingNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), 25 Avenue Tony Garnier, CS90627, Lyon, 69366, France.
Florian HerbolsheimerDivision of Physical Activity, Cancer Prevention and Survivorship, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg, 69120, Germany.ORCID http://orcid.org/0000-0002-2137-4082 Marie-Theres HuemerInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, Neuherberg, 85764, Germany.ORCID http://orcid.org/0000-0002-4329-8607 André KarchInstitute of Epidemiology and Social Medicine, University of Münster, Domagkstr. 3, Münster, 48149, Germany.
Rafael MikolajczykInstitute of Medical Epidemiology, Biometrics, and Informatics, Medical Faculty of the Martin-Luther-University Halle-Wittenberg, Magdeburger Straße 8, Halle (Saale), 0611206112, Germany.
Katharina NimptschMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Str. 10, Berlin, 13125, Germany.ORCID http://orcid.org/0000-0001-7877-205X Cara ÖvermöhleInstitute of Epidemiology, Kiel University, University Hospital Schleswig Holstein, Campus Kiel, Niemannsweg 11, 24105, Kiel, Germany.
Tobias PischonMolecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Str. 10, Berlin, 13125, Germany.ORCID http://orcid.org/0000-0003-1568-767X Steffen RinghofDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.ORCID http://orcid.org/0000-0003-1823-1037 Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Zweigertstr. 37, Essen, 45130, Germany.ORCID http://orcid.org/0000-0001-6948-7273 Karen SteindorfDivision of Physical Activity, Cancer Prevention and Survivorship, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg, 69120, Germany.ORCID http://orcid.org/0000-0001-5215-5651 Kerstin WirknerLIFE Research Center for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, Leipzig, 04103, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, Neuherberg, 85764, Germany.ORCID http://orcid.org/0000-0001-6645-0985 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundInsufficient physical activity is a leading global cause of premature mortality, yet how light-, moderate-, and vigorous-intensity activity differ in their associations with mortality and the implications of reallocating time across intensities remain unclear.
methodsWe prospectively analysed individually pooled baseline device-measured physical activity from 147,414 participants aged 40-74 years in the German National Cohort (NAKO) and UK Biobank, the largest pooled accelerometer dataset to date. Multivariable Cox models estimated hazard ratios (HR) and 95% confidence intervals (CI) for mortality across activity intensities and under time-reallocation models holding total active time constant.
resultsOver a mean follow-up of 7.9 years, 5,545 deaths occurred. Compared with no activity, 150 min per week of moderate-intensity activity was associated with lower mortality (HR: 0.70; 95% CI: 0.67, 0.72). Similar associations were observed for approximately 510 min per week of light-intensity activity or 12 min per week of vigorous-intensity activity. Additional activity beyond these levels was associated with further risk reduction. Replacing 15-60 min per week of light- or moderate-intensity activity with vigorous-intensity activity was associated with 18-30% lower mortality risk.
conclusionsPhysical activity at all intensities was associated with lower mortality, with vigorous-intensity activity showing strong inverse associations even at low volumes. Shifting modest amounts of active time toward higher intensities was associated with further risk reductions. These findings provide quantitative evidence to inform the interpretation of physical activity recommendations.
Indexed as
AccelerometryExerciseMortalityAdultAgedFemaleGermanyHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesUnited KingdomAccelerometryMortalityNAKOPhysical activity intensityUK Biobank
Identifiers
PMID42745313
PMCPMC13576285
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