Evidence map›Paper›PMID 42745100›Full record

ArticleNano-micro letters2026

Tailor-Made Nanoporous Metal-Organic Frameworks Via Molecular Engineering for Bilirubin-Specific Capture from Liver Failure Patients' Blood.

Shanshan Zhang, Jinming Zhang, Yihan Li, Dabao Shang, Ding Zhao, Fangke Zhang, Juan Wang, Liang Chen, Xiaogang Xiang, Wenguo Cui

Abstract read
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In one paragraph

Article in Nano-micro letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shanshan ZhangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China.
Jinming ZhangDepartment of Infectious Diseases, Translational Laboratory of Liver Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China.
Yihan LiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China.
Dabao ShangDepartment of Infectious Diseases, Translational Laboratory of Liver Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China.
Ding ZhaoDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China.
Fangke ZhangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China.
Juan WangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China.
Liang ChenSchool of Nursing, Shanghai Jiao Tong University, 227 South Chongqing Road, Shanghai, 200025, People's Republic of China. liangchen_cl@yeah.net.
Xiaogang XiangDepartment of Infectious Diseases, Translational Laboratory of Liver Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China. shine-xxg@163.com.
Wenguo CuiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2Nd Road, Shanghai, 200025, People's Republic of China. wgcui80@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overcoming the albumin-bilirubin binding barrier to achieve specific recognition and high-efficiency capture of blood bilirubin remains a major clinical challenge in treating patients with hyperbilirubinemia due to liver failure, cholestasis, or other related conditions. Here, a molecular engineering-assisted functionalization strategy is proposed: programming the coordination environment of nanocrystalline frameworks with monodentate carboxylic acid ligands of varied carbon chain lengths to construct a family of zirconium-based UiO-66 nanoporous frameworks that act as bilirubin-specific molecular capture traps. The experimental results and molecular dynamics simulations confirm that the newly engineered UiO-66 nanoporous framework rapidly enriched albumin-bound bilirubin through short-range van der Waals/electrostatic effects; the internal Zr-μ

Indexed as

Blood purificationMetal–organic frameworksMolecule engineeringNanocrystalsSpecific bilirubin capture

Identifiers

PMID42745100
PMCPMC13578141

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.