Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Systemic inflammatory profiles associated with early EEG abnormalities following ischemic stroke: a cohort study.
Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-stroke inflammation (PSI) contributes to acute brain injury and may influence early electroencephalographic (EEG) abnormalities after ischemic stroke. Although systemic inflammatory biomarkers have prognostic value, their association with specific EEG patterns - slow-wave activity (SA) and epileptiform discharges (ED) - remains unclear. We investigated the relationship between peripheral inflammatory markers and early EEG alterations following ischemic stroke.
methodsWe conducted a single-center, retrospective observational study including 307 patients with acute supratentorial ischemic stroke who underwent EEG within 72 h from admission. Peripheral inflammatory biomarkers were measured 24 h after admission. EEGs were classified according to the presence of SA and/or ED. Multivariable logistic regression analyses were performed to identify independent predictors of SA and ED. Predictive performance was assessed using receiver operating characteristic (ROC) analysis.
resultsAmong patients without ED (n = 248), no inflammatory biomarker remained independently associated with SA after multivariable adjustment. Stroke severity and hemorrhagic transformation were the main independent predictors of SA. In the overall cohort, ED (n = 59) were independently associated with higher white blood cell count (OR 1.15, 95% CI 1.02-1.31), neutrophil count (OR 1.19, 95% CI 1.05-1.36), and NLR (OR 1.08, 95% CI 1.01-1.15), after adjustment for relevant clinical variables. Neutrophil count showed the highest discriminative ability for ED and significantly improved model performance when added to clinical predictors.
conclusionsElevated neutrophil count is independently associated with early ED after ischemic stroke, supporting a role for systemic inflammation in acute post-stroke EEG hyperexcitability. In contrast, SA mainly reflects stroke severity and local complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.