Evidence map›Paper›PMID 42745033›Full record

ArticleCell death and differentiation2026

SMC1A is required for fate determinations of human spermatogonial stem cells and male fertility by interacting with YBX1 and stabilizing HMGA2 mRNA via an m

Wei Liu, Li Du, Yanna Zhu, Yuxuan Xu, Dai Zhou, Bang Liu, Jun Gao, Yinghong Cui, Wei Chen, Chunyun Li and 3 more

Abstract read
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In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei Liu *Key Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education, NHC Key Laboratory of Tropical Disease Control, Hainan Academy of Medical Sciences, Hainan Medical University School of Life Sciences and Medical Technology, Haikou, China.
Li Du *Department of Critical Medicine, Hunan Aerospace Hospital, Hunan Normal University, Changsha, China.
Yanna ZhuKey Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Basic Medicine, Changsha, China.
Yuxuan XuKey Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Basic Medicine, Changsha, China.
Dai ZhouHunan Provincial Key Laboratory of Regional Hereditary Birth Defect Prevention and Control, Changsha Hospital for Maternal and Child Health Care Affiliated to Hunan Normal University, Changsha, China.ORCID http://orcid.org/0000-0003-4577-8898
Bang LiuKey Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Basic Medicine, Changsha, China.
Jun GaoDepartment of Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
Yinghong CuiKey Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Basic Medicine, Changsha, China.
Wei ChenKey Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Basic Medicine, Changsha, China.
Chunyun LiKey Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Basic Medicine, Changsha, China.
Yongzhe ChenKey Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education, NHC Key Laboratory of Tropical Disease Control, Hainan Academy of Medical Sciences, Hainan Medical University School of Life Sciences and Medical Technology, Haikou, China.
Fen JiangKey Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University School of Basic Medicine, Changsha, China.
Zuping HeKey Laboratory of Reproductive Health Diseases Research and Translation, Ministry of Education, NHC Key Laboratory of Tropical Disease Control, Hainan Academy of Medical Sciences, Hainan Medical University School of Life Sciences and Medical Technology, Haikou, China. zupinghe@hunnu.edu.cn.ORCID http://orcid.org/0000-0003-3741-9350

Funding

National Science Foundation of China | Key Programme 32170862National Science Foundation of China | Key Programme 32470904
6 · The paper itself

Abstract

Spermatogonial stem cells (SSCs) are required for initiating and maintaining normal spermatogenesis, and notably, they have significant applications in both reproductive and regenerative medicine owing to their great plasticity with de-differentiation and trans-differentiation potentials. Nevertheless, molecular mechanisms regulating human SSC fate determinations and male fertility remain elusive. Here we report for the first time that structural maintenance of chromosomes 1A (SMC1A) interacts with RNA-binding protein YBX1 to control fate decisions of human SSCs and an association exists between SMC1A dysfunction with male infertility. SMC1A/YBX1 complex stabilizes high mobility group AT-hook 2 (HMGA2) mRNA in an m

Identifiers

PMID42745033

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.