ArticleAnalytical and bioanalytical chemistry2026
Intrinsic OPTIR imaging and spectroscopy enable label-free monitoring of viral infection in living cells.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Resolving biochemical signatures associated with viral infection progression within individual living cells, without introducing fluorescent labels that demand genetic accessibility and may perturb the process under study, remains a challenge for conventional optical approaches. Optical photothermal infrared (OPTIR) spectroscopy addresses this by providing label-free vibrational contrast with molecular bond specificity in live cells, combining submicron spatial resolution with strong suppression of the water background in aqueous media. Here, OPTIR discrete wavenumber imaging and point spectroscopy were applied to follow baculovirus infection in live Spodoptera frugiperda (Sf) 9 cells carrying no fluorescent reporter. Cells were measured within a CaF₂ sandwich configuration at 3, 6, 12, and 24 h post-infection. Imaging at the amide II protein band (1545 cm⁻
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