Association of miRNA (miR-10a, miR-30c, miR-181a, and miR-499b) Polymorphisms and Their Interactions with PAI-1 in Recurrent Implantation Failure in Korean Women.

Hui Jeong An, Sung Hwan Cho, Ji Eun Ko, Ji Hyang Kim, Hyeon Woo Park, Young Ran Kim, Eun Hee Ahn, Jin-Bae Kim, Nam Keun Kim

Abstract read

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In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hui Jeong AnDepartment of Biomedical Science, College of Life Science, CHA University, 335-Gil, Pangyo-Ro, Bundang-Gu, Seongnam, 13488, South Korea.

Sung Hwan ChoDepartment of Biomedical Science, College of Life Science, CHA University, 335-Gil, Pangyo-Ro, Bundang-Gu, Seongnam, 13488, South Korea.

Ji Eun KoDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, 13488, South Korea.

Ji Hyang KimDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, 13488, South Korea.

Hyeon Woo ParkDepartment of Biomedical Science, College of Life Science, CHA University, 335-Gil, Pangyo-Ro, Bundang-Gu, Seongnam, 13488, South Korea.

Young Ran KimDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, 13488, South Korea.

Eun Hee AhnDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, 13488, South Korea.

Jin-Bae KimDivision of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea. jinbbai@khu.ac.kr.

Nam Keun KimDepartment of Biomedical Science, College of Life Science, CHA University, 335-Gil, Pangyo-Ro, Bundang-Gu, Seongnam, 13488, South Korea. nkkim@cha.ac.kr.ORCID http://orcid.org/0000-0003-0541-3528

Funding

Korea Disease Control and Prevention Agency 2021-ER0904-02Korea Environmental Industry and Technology Institute RS-2022-KE002232Korea Health Industry Development Institute HI18C19990200National Research Foundation of Korea 2020R1I1A1A01072008National Research Foundation of Korea 2021R1I1A1A01050945National Research Foundation of Korea NRF-2020R1F1A107452511

6 · The paper itself

Abstract

Recurrent implantation failure (RIF) remains a major challenge in assisted reproductive technology, and accumulating evidence suggests that genetic factors, including microRNA (miRNA) polymorphisms, may influence implantation outcomes. This study investigated the association between RIF and polymorphisms in miR-10a A > T, miR-30c A > G, miR-181a T > C, and miR-499b A > G in Korean women. Peripheral blood samples were obtained from 169 women with RIF and 281 fertile controls, and genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism and real-time polymerase chain reaction. While individual miRNA polymorphisms were not independently associated with RIF in the overall population, subgroup analyses revealed that the miR-499b AG genotype was significantly associated with increased risk in women with ≥ 4 implantation failures (AOR = 1.908, P = 0.021). Stratified analysis showed that the miR-181a TC + CC genotype increased RIF risk in women with lower platelet counts, whereas the miR-30c AG + GG genotype consistently exerted a protective effect, particularly in subjects with a BMI ≥ 25 kg/m

Indexed as

Embryo ImplantationMicroRNAsPlasminogen Activator Inhibitor 1Polymorphism, Single NucleotideAdultCase-Control StudiesEast Asian PeopleFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansRepublic of KoreaMicroRNAsMIRN10 microRNA, humanMIrn181 microRNA, humanMIRN30a microRNA, humanMIRN30b microRNA, humanMIRN499 microRNA, humanPlasminogen Activator Inhibitor 1SERPINE1 protein, humanMicroRNARecurrent implantation failureSingle nucleotide polymorphism (SNP)

Identifiers

PMID42745021

DOI10.1111/j.1600-0897.2010.00946.x

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.