ArticleNature human behaviour2026
Loneliness and desire for thinness explain sex differences in adolescent internalizing problems.
Article in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Girls are at higher risk of internalizing problems than boys. This disparity has widened in recent decades, but the underlying mechanisms remain understudied. Here we analysed data from 3,171 adolescents (46.9% girls) within the Tokyo Teen Cohort, assessed at ages 12, 14 and 16 years. At age 16, girls showed higher prevalence of internalizing problems than boys: depressive symptoms (15.9% versus 8.2%) and suicidal ideation (29.8% versus 18.1%). Coproduction with young people suggested loneliness and desire for thinness as candidate pathways. Using the mediational g-formula, we estimated that the effect through these factors at age 14 relative to the total effect of female sex was 34.7% for depressive symptoms and 46.3% for suicidal ideation at age 16. These findings suggest that social intermediates may contribute to the higher prevalence of internalizing problems among girls in this cohort, highlighting potential targets for interventions and policies informed by young people.
Identifiers
42745003What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.