ArticleInternational orthopaedics2026
Early postoperative serum metal profiles and subsequent revision-related surgery after instrumented fusion for adolescent idiopathic scoliosis.
Article in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundCirculating titanium (Ti), cobalt (Co), and chromium (Cr) can increase after spinal instrumentation for adolescent idiopathic scoliosis (AIS), but their relation to later revision surgery is uncertain.
methodsThis was a single-centre retrospective prognostic model-development study with a six month landmark. The cohort comprised 154 patients with AIS who underwent posterior instrumented fusion and had serum Ti, Co, and Cr measured at one and six months. Only revision-related procedures performed after six months were counted as outcomes. Log₂-transformed metal concentrations were examined in prespecified logistic models. Performance was assessed by AUC, Brier score, calibration, decision curve analysis, and risk-stratum event rates. Internal validation used 1000 bootstrap resamples to estimate optimism-corrected AUCs and Brier scores.
resultsSixty patients underwent later revision-related surgery and 94 did not. Ti and Co were higher in the revision group, with the largest difference for Ti at one month. The primary one month Ti/Co/Cr model had an apparent AUC of 0.926 and an optimism-corrected AUC of 0.918. The corresponding Brier scores were 0.099 and 0.108. Revision rates across predicted-risk were 3.8%, 23.5%, and 90.2%. In a sensitivity analysis restricted to implant loosening, the optimism-corrected AUC was 0.876.
conclusionsEarly postoperative serum metal profiles were associated with later revision-related surgery after AIS fusion. The one month Ti/Co/Cr model provided the most favourable balance between early availability, parsimony, and discrimination. Its clinical utility requires external validation and comparison with conventional clinical and imaging predictors.
Indexed as
Identifiers
42744993What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.