Evidence map›Paper›PMID 42744910›Full record

ArticleNature metabolism2026

Cysteine excess triggers a mitochondrial iron-dependent cell death.

Toshitaka Nakamura, Ayaka Inoki, Nupur K Das, Brandon Chen, Artem Khan, Yuyang Liu, Beste Uygur, Frederick S Yen, Gokhan Unlu, Yatrik M Shah and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Toshitaka NakamuraLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-4248-2058
Ayaka InokiLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Nupur K DasDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5652-1134
Brandon ChenLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Artem KhanLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Yuyang LiuLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-5632-7764
Beste UygurLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0528-9099
Frederick S YenLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Gokhan UnluLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2704-2724
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2487-4816
Kıvanç BirsoyLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA. kbirsoy@rockefeller.edu.ORCID http://orcid.org/0000-0002-7579-9895

Funding

Weill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6M
U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1K99CA286722-01U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM152349
6 · The paper itself

Abstract

Thiol-containing metabolites are central to cellular redox homeostasis

Identifiers

PMID42744910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.