Evidence map›Paper›PMID 42744886›Full record

ArticleNature chemical biology2026

Biosynthetic allene and alkyne formation by enzymatic prenyl demethylation.

Mengting Liu, Masao Ohashi, Wenyu Han, Qingyang Zhou, Kendall N Houk, Yi Tang

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mengting LiuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Masao OhashiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. gph422001@ucla.edu.ORCID http://orcid.org/0000-0001-7103-541X
Wenyu HanDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Qingyang ZhouDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Kendall N HoukDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. houk@ucla.edu.ORCID http://orcid.org/0000-0002-8387-5261
Yi TangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA. yitang@ucla.edu.ORCID http://orcid.org/0000-0003-1597-0141

Funding

MIRA: Enzymology and Self-Resistance of Natural Product BiosynthesisR35GM118056 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yi Tang · 2016 to 2026
$6.1M
National Science Foundation (NSF) CHE-2153972U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM118056
6 · The paper itself

Abstract

Allenes and alkynes are versatile functional groups in chemical biology and drug discovery. However, how nature biosynthetically installs them in natural products, especially allenes, remains poorly understood. Here we uncovered that allenes and alkynes can be formed enzymatically through oxidative C(sp

Identifiers

PMID42744886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.