Evidence map›Paper›PMID 42744804›Full record

ArticleNature communications2026

Microglia deploy TAM receptors to kill motor neurons in a mouse model of amyotrophic lateral sclerosis.

Youtong Huang, Ananya Mavinkurve, Bristy Sabikunnahar, Beth Stevens, Greg Lemke

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Youtong HuangMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-4752-5800
Ananya MavinkurveF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0009-0000-2598-1552
Bristy SabikunnaharF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Beth StevensF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-4226-1201
Greg LemkeMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. lemke@salk.edu.ORCID 0000-0001-5805-9855

Funding

TAM Receptors and Virus InfectionR01AI101400 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI DIAMOND, MICHAEL S, KLEIN, ROBYN S. · 2012 to 2021
$5.8M
Mechanisms of Activity-dependent Microglia-neuron Interactions in Development and DiseaseRF1NS092578 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI STEVENS, BETH ANN, UMEMORI, HISASHI · 2021 to 2023
$3.5M
NIAID NIH HHS R01 AI101400NINDS NIH HHS RF1 NS092578U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AI101400U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1 AG0600748U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1 NS092578
6 · The paper itself

Abstract

Activation of microglia is a prominent feature of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that leads to the death of motor neurons. A key component of this activation is elevated expression of the TAM receptor tyrosine kinases Axl and Mer (gene name Mertk). Here we show that germline and microglial-restricted inactivation of the Axl and Mertk genes in the SOD1

Indexed as

Amyotrophic Lateral Sclerosisc-Mer Tyrosine KinaseMicrogliaMotor NeuronsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesAnimalsAxl Receptor Tyrosine KinaseCholinergic NeuronsDisease Models, AnimalEfferocytosisFemaleHumansLysosomesMiceMice, KnockoutAxl Receptor Tyrosine KinaseAXL receptor tyrosine kinase, mousec-Mer Tyrosine KinaseMertk protein, mouseProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSod1 protein, mouseSuperoxide DismutaseSuperoxide Dismutase-1

Identifiers

PMID42744804
PMCPMC13578243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.