Thermal-feedback modality switchable hydrogel with thermoelectric self-modulation for stage-adaptive repair of infected diabetic wound.

Yutong Yang, Qingqing Fang, Tianyu Shu, Wenjia Liu, Yuchen Sun, Xiao Liu, Meng Li, Baolin Guo

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yutong Yang *State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Qingqing Fang *State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Tianyu ShuKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

Wenjia LiuDepartment of Urology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Yuchen SunState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Xiao LiuState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Meng LiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.ORCID 0000-0001-7914-395X

Baolin GuoState Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China. baoling@mail.xjtu.edu.cn.ORCID 0000-0001-6756-1441

Funding

National Natural Science Foundation of China (National Science Foundation of China) 52573176

6 · The paper itself

Abstract

Hyperthermia is a promising strategy for chronic wound management, with efficacy critically dependent on precise temperature control. Current strategies largely rely on two discrete modes: high-temperature bactericidal ablation or mild hyperthermia to promote tissue regeneration. Enabling hyperthermia to autonomously match the thermal requirements of each wound-healing stage remains challenging. Herein, we developed a biomimetic thermal-feedback modality switchable (TFMS) hydrogel, obtained by copolymerizing N-isopropylacrylamide with sulfobetaine vinylimidazolium (SBVI) and loading glucose oxidase (GOx) together with EGCG-Fe

Indexed as

HydrogelsHyperthermia, InducedWound HealingWound InfectionAcrylamidesAnimalsAnti-Bacterial AgentsDiabetes Mellitus, ExperimentalGlucose OxidaseHumansMiceAcrylamidesAnti-Bacterial AgentsGlucose OxidaseHydrogelsN-isopropylacrylamide

Identifiers

PMID42744768

DOI10.1038/s41467-026-76553-w

PMCPMC13578289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.