ArticleJournal of applied clinical medical physics2026
Preclinical feasibility of EPID-based transit dosimetry for total body irradiation.
Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundConventional extended-distance total body irradiation (TBI) is commonly verified using point dosimeters, which provide limited spatial information and require additional handling during a prolonged treatment procedure. A portable charge-coupled device (CCD)-based electronic portal imaging device (EPID) positioned downstream of the patient may provide wider-area transit information in a geometry in which a gantry-mounted EPID cannot readily be used. PURPOSE: To develop and perform preclinical phantom validation of a CCD-EPID method for transit dose estimation during fixed-field long-SSD TBI and to identify the calibration and normalization factors relevant to subsequent patient validation.
methodsA portable CCD-based EPID was positioned at 400 cm, with water-equivalent or anthropomorphic phantoms centered at 350 cm. Direct-irradiation characteristics were evaluated for 4- and 10-MV photon beams, including signal response to dose-rate/delivered MU, field size, short-term frame reproducibility, and in-plane response. For ETD calibration, 6-36-cm-thick water-equivalent phantoms were irradiated with 10-MV photons using 1000 MU at 600 MU/min and a 10 × 10 cm
resultsThe 10-MV EPID signal was highly linear with dose rate/delivered MU (r = .999) and field size (r = .995). Flatness was 1.4% and 1.3%, and symmetry was .3% and 1.4%, in the ceiling-floor and gun-target directions, respectively. The summed EPID signal-to-ionization-chamber dose relationship showed R
conclusionsThis preclinical phantom study demonstrates the feasibility of wide-area CCD-EPID transit-dose estimation for conventional long-SSD TBI. Agreement in homogeneous phantoms supports the calibration approach, while the positive RANDO bias identifies the need for same-day sensitivity normalization and further validation in repeated anthropomorphic, heterogeneous, lung-shielded, and full-clinical-field conditions before patient application.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.