Evidence map›Paper›PMID 42744368›Full record

ArticleBMJ open2026

Volume removal intolerance during net ultrafiltration in patients with acute kidney injury in the intensive care unit: protocol for a prospective multicentre observational study (VINKO).

Gonzalo Ramírez-Guerrero, Cristian Pedreros-Rosales, Pablo Galindo, Rodrigo Ulloa, Jonathan Alarcón, Sandra Ávila, Eduardo Kattan, Paulo Melo, David Ballesteros, Raúl Valenzuela and 8 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07643597 (Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07643597 recruitingnot on this map

Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients

TypeobservationalSponsorHospital Las HiguerasRan2026 to 2027Enrolled128ConditionsAcute Kidney Injury, Fluid Overload, Fluid Overload in Dialysis Patients, Critical Illness
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gonzalo Ramírez-GuerreroNephrology Service, Hospital las Higueras, Talcahuano, Chile ramirezguerrero.g@gmail.com.ORCID http://orcid.org/0000-0002-1696-9997
Cristian Pedreros-RosalesNephrology Service, Hospital las Higueras, Talcahuano, Chile.
Pablo GalindoDepartment of Nephrology, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, CDMX, Mexico.
Rodrigo UlloaUnidad de Cuidados Intensivos, Hospital las Higueras, Talcahuano, Chile.
Jonathan AlarcónNephrology Service, Hospital las Higueras, Talcahuano, Chile.
Sandra ÁvilaDepartment of Nephrology, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, CDMX, Mexico.
Eduardo KattanDepartamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Paulo MeloDepartamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
David BallesterosNephrology Service, Hospital Universitario San José, Popayán, Colombia.
Raúl ValenzuelaServicio Nefrología, Hospital Nacional Cayetano Heredia, Lima District, Peru.
Gabriela GuimaraesPost-Graduate Program on Health Sciences, Federal University of Bahia, Salvador, Brazil.
Ricardo FerradaNephrology Service, Hospital las Higueras, Talcahuano, Chile.
Charlotte PfeiferNephrology Service, Hospital las Higueras, Talcahuano, Chile.
Vivian VillalobosNephrology Service, Hospital las Higueras, Talcahuano, Chile.
Gianpiero MasNephrology Service, Hospital las Higueras, Talcahuano, Chile.
Matteo MarcelloInternational Renal Research Institute of Vicenza (IRRIV), San Bortolo Hospital of Vicenza, Vicenza, Veneto, Italy.
Gerd KlinkmannDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Center Rostock, Rostock, MV, Germany.
Claudio RoncoInternational Renal Research Institute of Vicenza (IRRIV), San Bortolo Hospital of Vicenza, Vicenza, Veneto, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFluid overload in critically ill patients with acute kidney injury (AKI) is independently associated with increased mortality, prolonged mechanical ventilation and impaired renal recovery. Net ultrafiltration (UF METHODS AND ANALYSIS: VINKO is a prospective, multicentre, observational analytical case-control study enrolling adult intensive care unit patients with AKI requiring CRRT with prescribed UF ETHICS AND DISSEMINATION: The study has been approved by the Scientific Ethics Committee of the Talcahuano Health Service (Act No. 15, 14 April 2026) and will be conducted in accordance with the Declaration of Helsinki, Council for International Organizations of Medical Sciences (CIOMS) guidelines and current Chilean regulations. Results will be disseminated through presentations at scientific meetings and publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT07643597.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyCase-Control StudiesCritical IllnessHemodynamicsHumansIntensive Care UnitsMulticenter Studies as TopicObservational Studies as TopicProspective StudiesResearch DesignUltrafiltrationAcute renal failureAdult nephrologyDialysis

Identifiers

PMID42744368
PMCPMC13583866

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.