Evidence map›Paper›PMID 42744304›Full record

ArticleNature2026

Quality control of glycogen through direct ubiquitylation by RNF213.

Matthew C J Yip, Katerina Naydenova, Elsje G Otten, Alexander Heatley, Agnes Moe, Leonie Anton, Lucía de Los Reyes-Ramírez, Helen E Jolin, Frederic Langevin, Michal Wiacek and 5 more

Abstract read
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In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matthew C J YipProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-2505-9987
Katerina NaydenovaProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Elsje G OttenProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Alexander HeatleyProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0009-0004-0789-2467
Agnes MoeInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Leonie AntonInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-0008-2141
Lucía de Los Reyes-RamírezNeurobiology Division, MRC Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0001-7880-1199
Helen E JolinProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Frederic LangevinProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Michal WiacekProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Catarina FrancoProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Anne BertolottiNeurobiology Division, MRC Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-9185-0558
Wanda KukulskiInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-2778-3936
Andrew N J McKenzieProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0001-9757-2512
Felix RandowProtein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, UK. randow@mrclmb.ac.uk.ORCID http://orcid.org/0000-0003-0694-5315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quality control of biomolecules is vital for organismal health. Although DNA repair and protein quality control are well understood, how cells monitor other important biomolecules such as glycogen remains ill defined. Accumulation of aberrant, poorly branched glycogen into insoluble polyglucosan bodies causes severe disease

Identifiers

PMID42744304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.