ArticleClinical nutrition ESPEN2026
Plasma polyunsaturated fatty acid metabolism associations with bone mineral density and bone turnover in pre- and postmenopausal women living with HIV.
Article in Clinical nutrition ESPEN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundWomen living with HIV (WLWH) are at high-risk of osteoporosis and fracture. Studies suggest that polyunsaturated fatty acid (PUFA) metabolism may modulate bone mineral density (BMD) in populations without HIV. We aimed to use untargeted high-resolution metabolomics (HRM) to profile the plasma metabolome and identify biochemical pathways and metabolites associated with indices of bone health in WLWH. A secondary objective was to assess the association between plasma PUFA concentrations and bone health indices.
methodsIn a cross-sectional study of WLWH (n = 68) and women without HIV (n = 42), BMD at the lumbar spine, femoral neck, and total hip was determined by dual energy X-ray absorptiometry. Serum concentrations of bone turnover markers, C-terminal telopeptide of type I collagen (CTX) and osteocalcin (OCN), were determined. Plasma HRM and pathway enrichment analysis were conducted by HIV status to determine associations of each BMD Z-score and bone turnover markers with the plasma metabolome. Relationships between plasma PUFA concentrations and each BMD index and bone turnover marker were assessed by multivariable linear regression.
resultsThe median age was 49 (Q1, Q3: 41, 56) years and median Z-scores for lumbar spine, total hip, and femoral neck BMD were -0.2 (-1.2, 0.7), -0.5 (-1.3, 0.2), and -0.8 (-1.4, 0.1), respectively, with no significant differences between HIV status groups (all p > 0.05). Among WLWH, BMD Z-scores were associated with metabolites significantly enriched in metabolic pathways including those related to arachidonic acid, fatty acid oxidation, energy metabolism, and steroid hormones (all p < 0.05). Bone turnover markers were associated with metabolites significantly enriched in multiple metabolic pathways, including PUFA and other lipid metabolic pathways (all p < 0.05). Plasma n-3 and n-6 PUFA concentrations were not significantly associated with BMD Z-scores or serum bone turnover markers (all p > 0.05).
conclusionsThis study demonstrates linkages between PUFA metabolism and bone health in WLWH providing potential targets for focused interventions to improve bone health in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.