Evidence map›Paper›PMID 42744017›Full record

ArticlePhysiology & behavior2026

A microstructural analysis of sodium and water intake in male and female rats.

Emily Demieri, Emalie L Mullane, Kennedy L Lamb, Andrea A Edwards, Samantha L Brooker, Sydney A David, Derek Daniels, Ann-Marie Torregrossa, Jessica Santollo

Abstract read
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In one paragraph

Article in Physiology & behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emily DemieriDepartment of Psychology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Emalie L MullaneDepartment of Biology, University of Kentucky, Lexington, KY, 40508, USA.
Kennedy L LambDepartment of Biology, University of Kentucky, Lexington, KY, 40508, USA.
Andrea A EdwardsDepartment of Biology, University of Kentucky, Lexington, KY, 40508, USA.
Samantha L BrookerDepartment of Psychology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Sydney A DavidDepartment of Psychology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Derek DanielsDepartment of Biological Sciences, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Center for Ingestive Behavior Research, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Ann-Marie TorregrossaDepartment of Psychology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA; Center for Ingestive Behavior Research, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Jessica SantolloDepartment of Biology, University of Kentucky, Lexington, KY, 40508, USA. Electronic address: j.santollo@uky.edu.

Funding

Parsing the central control of thirst and hunger using a rat model of diabetes insipidusR01DK133818 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DANIELS, DEREK · 2022 to 2025
$2.1M
NIDDK NIH HHS R01 DK133818
6 · The paper itself

Abstract

Analysis of fluid intake microstructure is a powerful tool to provide insight into the mechanisms underlying ingestion. Foundational work demonstrated that changes in the number of licking bursts reflect changes in negative feedback related to satiety, whereas the average size of those bursts reflects changes in the hedonic value of the substance being consumed. These conclusions, however, were drawn primarily from studies of sucrose intake, and it is unclear if the interpretation can be extended to intake of water or sodium. To address this open question, we first tested and found support for the hypothesis that dehydrated rats would show a concentration-dependent decrease in sodium intake that is the result of reduced burst size, without differences in burst number. Next, we tested if a preference for cold water over tepid water was a function of burst size. We found that rats preferred 10°C water over 40°C water, and that the difference in intake was a function of both burst size and burst number. To test this in a condition with a reduced influence of satiation, we repeated this experiment using polydipsic Brattleboro rats. Like the rats in the second experiment, we found that Brattleboro rats preferred 10°C water over 40°C water, but the difference was mediated only by burst size and not burst number. Together, these findings support the conclusion that burst size can be used to measure changes in the hedonic value of sodium and water.

Indexed as

DrinkingDrinking BehaviorSex CharacteristicsAnimalsDehydrationFemaleFood PreferencesMaleRatsRats, Sprague-DawleyTemperatureWaterWaterHedonic evaluationLick microstructurePost-oral satietySalt appetiteSex differencesThirst

Identifiers

PMID42744017
PMCPMC13639896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.