ArticleBiofabrication2026
Optogenetic-enabled biomanufacturing of long-projecting motor tracts for neural reconstruction.
Justin C Burrell, Vishal J Tien, Phuong T Vu, David R Clizbe, Michael Spadola, Yohannes Ghenbot, Ali K Ozturk, D Kacy Cullen
Abstract read
In one paragraphArticle in Biofabrication, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Justin C BurrellCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-5361-9224 Vishal J TienCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-6408-6224 Phuong T VuCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
David R ClizbeCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Michael SpadolaCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Yohannes GhenbotCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Ali K OzturkCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
D Kacy CullenCenter for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-5355-5216 Funding
NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0MTissue Engineered Nigrostriatal Pathway for Anatomical Tract Reconstruction in Parkinson's DiseaseR01NS127895 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Daniel Kacy Cullen · 2023 to 2026
$2.3MTissue Engineered Motor Units for Neuromuscular Modeling and RepairR01AR083489 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Daniel Kacy Cullen · 2024 to 2026
$1.7MAdvanced Training at the Interface of Engineering and Oral-Craniofacial SciencesT90DE030854 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI Hyun Koo, Kathleen J Stebe · 2021 to 2026
$1.4MBLRD VA I01 BX003748NCATS NIH HHS TL1 TR001880NIAMS NIH HHS R01 AR083489NIDCR NIH HHS T90 DE030854NINDS NIH HHS R01 NS127895RRD VA I01 RX005045
6 · The paper itselfAbstract
Tissue-engineered spinal tracts (TE-STs), a subclass of micro-tissue-engineered neural networks, are designed to replace long-range axonal pathways but are limited by the slow intrinsic growth of many neuronal subtypes, particularly spinal motor neurons. Optogenetic stimulation provides cell-type-specific, precise control of activity that may accelerate neurite extension during biofabrication. Accordingly, this study evaluates whether integrating optogenetic stimulation into the biomanufacturing process enhances motor axonal outgrowth within tailored hydrogel micro-columns
Indexed as
Motor NeuronsOptogeneticsSpinal CordTissue EngineeringAnimalsAxonsRatsaxon outgrowthbiomanufacturingengineered micro-tissueneural tissue engineeringoptogenetics
Identifiers
PMID42743986
PMCPMC13659052
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