ArticleAmerican journal of physiology. Heart and circulatory physiology2026
A biphasic effect of alcohol on endothelial plasticity through regulation of endothelial-to-mesenchymal transition.
Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alcohol influences cardiovascular disease, but whether it does so by affecting endothelial plasticity is unknown. We tested whether alcohol regulates endothelial-to-mesenchymal transition (EndMT) to influence arterial pathology. Human coronary artery endothelial cells (HCAEC) and human umbilical vein endothelial cells (HUVEC) were exposed to inflammatory cytokines or hypoxia in the absence or presence of ethanol (5-100 mM). In vivo, carotid ligation was performed in mice gavaged with/without either daily moderate ethanol (2 drinks equivalent/day) or episodic binge exposure (7 drinks equivalent, 2 days/wk) and myoendothelial cells assessed. Cytokines and hypoxia induced EndMT in vitro characterized by loss of endothelial markers, increased mesenchymal markers, and enhanced migratory capacity. Low-to-moderate-dose ethanol (5-25 mM) attenuated marker changes, preserving endothelial phenotype, whereas high-dose ethanol (50-100 mM) either had no effect or exacerbated EndMT. The inhibitory effect of moderate-dose ethanol on cytokine- and hypoxia-induced changes in α-smooth muscle actin (αSMA) and cadherin-5 (
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