ArticlePloS one2026
The pathway analysis of relationship between illness uncertainty, perceived stress, coping strategies, and quality of life in patients with coronary artery disease.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies suggests that illness uncertainty is associated with quality of life in chronic illness, yet the underlying mechanisms remain unclear, particularly in coronary artery disease (CAD). This study aims to explore the relationship between uncertainty in illness, perceived stress, coping strategies, and quality of life in patients with coronary artery disease.
methodsThis cross-sectional study was conducted in 150 patients with CAD recruited at a specialized heart clinic affiliated with Tabriz University of Medical Sciences, Tabriz (Iran) in 2024. Uncertainty in illness, perceived stress, coping strategies, and QoL were evaluated through self-reported questionnaires. The multiple mediation model was analyzed using SPSS and Amos software, with a P-value of less than 0.05 considered significant.
resultsThe mean (SD) scores of uncertainty in illness, perceived stress, coping strategies, physical, and psychological quality of life were 66.77 (11.97) (in a range of 23-115), 29.57 (4.96), 59.91 (10.32), 11.95 (2.90), and 16.48 (1.69), respectively. The Pearson correlation indicated a significant positive correlation between uncertainty in illness and perceived stress (r = 0.50, P < 0.001). Additionally, uncertainty in illness was negatively and significantly correlated with coping strategies (r = -0.41, P < 0.001) and physical QoL (r = -0.32, P < 0.001). There was also a significant negative correlation between perceived stress and coping strategies (r = -0.29, P < 0.001) as well as between perceived stress and physical QoL (r = -0.37, P < 0.001). Furthermore, a significant positive correlation was found between psychological QoL and physical QoL (r = 0.39, P < 0.001).
conclusionsUncertainty in illness and perceived stress are important factors that affect QoL in patients with coronary artery disease. It is recommended to implement well-structured interventions aimed at decreasing illness uncertainty and perceived stress while improving physical quality of life in patients with coronary artery disease.
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