Evidence map›Paper›PMID 42743118›Full record

ArticlePloS one2026

Prevalence and factors associated with anemia among patients with type 2 diabetes mellitus in northeastern Thailand: A cross-sectional study.

Khomsan Yooyen, Seubsiri Bunditpirom, Supan Fucharoen, Attawut Chaibunruang, Hataichanok Srivorakun, Supawadee Yamsri

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Khomsan YooyenDoctor of Philosophy in Medical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand.
Seubsiri BunditpiromNonsaad Hospital, Udon Thani, Thailand.
Supan FucharoenThe Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen Universyugbity, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0001-9142-5079
Attawut ChaibunruangThe Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen Universyugbity, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0002-2784-2449
Hataichanok SrivorakunThe Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen Universyugbity, Khon Kaen, Thailand.
Supawadee YamsriThe Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen Universyugbity, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0002-5887-4216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAnemia is a common complication in individuals with type 2 diabetes mellitus (T2DM), particularly in regions where thalassemia and iron deficiency are prevalent. However, the relative contribution of genetic hemoglobin disorders in this context has not been well characterized. This study aimed to determine the prevalence of anemia and to identify factors associated with its occurrence among patients with T2DM in northeastern Thailand.

methodsA cross-sectional study was conducted among 210 patients with T2DM attending two community health-promoting hospitals in northeastern Thailand. Data on sociodemographic characteristics, hematologic indices, renal function, iron status, and thalassemia genotypes were collected. Anemia was defined according to World Health Organization criteria. Factors associated with anemia were evaluated using multivariable logistic regression analysis, and adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were reported.

resultsThe prevalence of anemia was 54.3%. Thalassemia and related hemoglobinopathies were present in 60.5% of participants, and iron deficiency in 39.5%. Independent predictors of anemia included two or more α-globin gene defects or Hb E co-inherited with α-thalassemia (adjusted OR: 37.8; p = 0.002), Hb E trait (OR: 3.6; p = 0.006), iron deficiency (OR: 3.7; p < 0.001), and chronic kidney disease stages 2 (OR: 3.5; p = 0.002) and 3-4 (OR: 15.7; p < 0.001).

conclusionAnemia was highly prevalent among patients with T2DM in this community-based cohort from northeastern Thailand. Thalassemia-related genotypes, iron deficiency, and chronic kidney disease were significantly associated with anemia. These findings highlight the importance of considering inherited hemoglobin disorders when evaluating anemia in T2DM patients in hemoglobinopathy-endemic regions.

Indexed as

AnemiaDiabetes Mellitus, Type 2AdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsThailand

Identifiers

PMID42743118
PMCPMC13577357

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