Evidence map›Paper›PMID 42742889›Full record

ArticleGeroScience2026

Association between a disease-specific frailty index and long-term quality of life outcomes in older adult patients with traumatic brain injury: a TRACK-TBI study.

Deepti K Tantry, Vikas N Vattipally, Jason Barber, Nancy R Temkin, Geoffrey T Manley, David O Okonkwo, Claudia S Robertson, Joseph T Giacino, Michael A McCrea, Lindsay D Nelson and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Deepti K TantryDepartment of Neurosurgery, Johns Hopkins University, 1800 Orleans St., Baltimore, MD, 21287, USA.
Vikas N VattipallyDepartment of Neurosurgery, Johns Hopkins University, 1800 Orleans St., Baltimore, MD, 21287, USA.
Jason BarberDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Nancy R TemkinDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Geoffrey T ManleySan Francisco Department of Neurological Surgery, University of California, San Francisco, CA, USA.
David O OkonkwoDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.
Claudia S RobertsonBaylor College of Medicine Department of Neurosurgery, Waco, TX, USA.
Joseph T GiacinoDepartment of Psychiatry and Department of Physical Medicine and Rehabilitation, Harvard University, Boston, MA, USA.
Michael A McCreaMedical College of Wisconsin Department of Neurosurgery, Milwaukee, WI, USA.
Lindsay D NelsonMedical College of Wisconsin Department of Neurosurgery, Milwaukee, WI, USA.
Randall ChesnutDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Shankar GopinathBaylor College of Medicine Department of Neurosurgery, Waco, TX, USA.
Ramesh GrandhiDepartment of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, WA, USA.
Vijay KrishnamoorthyDepartment of Anesthesiology, Duke University, Durham, NC, USA.
Christine Mac DonaldDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Randall MerchantDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA.
Pratik MukherjeeSan Francisco Department of Radiology, University of California, San Francisco, CA, USA.
Laura B NgwenyaDepartment of Neurosurgery, University of Cincinnati, Cincinnati, OH, USA.
David SchnyerDepartment of Psychology, University of Rhode Island, Kingston, RI, USA.
Sabrina R TaylorSan Francisco Department of Clinical Studies, University of California, San Francisco, CA, USA.
John K YueSan Francisco Department of Neurological Surgery, University of California, San Francisco, CA, USA.
Ross ZafonteDepartment of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA.
John R WilliamsMcGovern Medical School Department of Neurosurgery, Houston, TX, USA.
Nicholas TheodoreDepartment of Neurosurgery, Johns Hopkins University, 1800 Orleans St., Baltimore, MD, 21287, USA.
Tej D AzadDepartment of Neurosurgery, Johns Hopkins University, 1800 Orleans St., Baltimore, MD, 21287, USA. tazad1@jhmi.edu.ORCID http://orcid.org/0000-0001-7823-4294
Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a significant public health concern, particularly in aging populations. While advanced age and frailty affect outcomes after TBI, the independent effect of frailty on long-term outcomes in geriatric TBI patients remains poorly understood. We hypothesized that higher disease-specific frailty is independently associated with poor long-term outcomes and quality of life following TBI. To determine whether a TBI-specific frailty index assessed at presentation is associated with long-term functional outcomes in older adults with TBI. We performed a secondary analysis of the TRACK-TBI cohort, restricting to patients ≥ 65 years. Frailty was quantified using a TRACK-TBI frailty index. Primary outcomes were 12-month Extended Glasgow Outcome Scale (GOSE), Quality of Life after Brain Injury (QoLIBRI), and Wechsler Adult Intelligence Scale Processing Speed Index (WAIS-PSI). Secondary outcomes included 6-month measures, inpatient mortality/discharge alive status, and discharge disposition. Associations were evaluated using adjusted regression models. The sample included 358 geriatric TBI patients (median age 72 years). Frail patients presented with worse admission assessments and higher incidence of TBI-related injuries. Higher frailty was independently associated with lower quality of life: adjusted mean 12-month QoLIBRI was 10.9 points lower in frail patients (95% CI 2.9-18.8; P = 0.007). High-frailty patients had lower odds of favorable 12-month GOSE (adjusted OR 0.54; 95% CI 0.29-1.03; P = 0.06). No adjusted differences were observed for WAIS-PSI. Among older adults with TBI, higher frailty at presentation was independently associated with worse quality of life. These findings suggest that frailty assessment may provide prognostic information for risk stratification and patient counseling in geriatric TBI, warranting further prospective evaluation.

Indexed as

AgingFrailtyGeriatricsTraumatic brain injury

Identifiers

PMID42742889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.