Evidence map›Paper›PMID 42742874›Full record

ArticleMedical oncology (Northwood, London, England)2026

Intratumoral PD-1

Dan Liu, Zirui Xue, Kuan Yu, Zhaodong Sun, Guoxing Ma, Junjie Zhao, Haojie Li, Yihong Sun, Zhaoming Wang, Xuefei Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dan Liu *Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zirui Xue *Department of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Kuan YuDepartment of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhaodong SunDepartment of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Guoxing MaDepartment of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Junjie ZhaoDepartment of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Haojie LiDepartment of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yihong SunDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhaoming WangDepartment of Gastrointestinal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. wang.zhaoming@zs-hospital.sh.cn.
Xuefei WangDepartment of General Surgery, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. wang.xuefei@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-2645-0953

Funding

National Natural Science Foundation of China 82403871Shanghai Pu Jiang Program 23PJ1401400
6 · The paper itself

Abstract

purposePD-1 and LAG-3 are frequently used as markers of T cell exhaustion, yet the prognostic relevance and phenotypic characteristics of PD-1

methodsFour independent GC cohorts were analyzed: the Zhongshan Hospital cohort (ZSGC, n = 298), The Cancer Genome Atlas cohort (TCGA, n = 371), an Immune Checkpoint Blockade cohort (ICB, n = 45), and the Yonsei cohort (n = 433). Intratumoral PD-1

resultsPD-1

conclusionsHigh intratumoral infiltration of PD-1

Indexed as

Antigens, CDCD8-Positive T-LymphocytesLymphocytes, Tumor-InfiltratingProgrammed Cell Death 1 ReceptorStomach NeoplasmsAgedBiomarkers, TumorFemaleHumansLymphocyte Activation Gene 3 ProteinMaleMiddle AgedPrognosisT-Cell ExhaustionTumor MicroenvironmentAntigens, CDBiomarkers, TumorLag3 protein, humanLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorGastric cancerLAG-3PD-1PrognosisTumor microenvironment

Identifiers

PMID42742874

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.