Evidence map›Paper›PMID 42742826›Full record

ReviewDigestive diseases and sciences2026

Diagnosing and Managing the High-Output Ileostomy: A Comprehensive Narrative Literature Review.

Calista Harbaugh, Deepa Chandhrasekhar, Evan Monge, Emily Haller, Kelli Gibbs, Amanda Lynett, Scott Regenbogen, Michael Rice, Samantha Hendren

Abstract readReview
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In one paragraph

Review in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Calista HarbaughDepartment of Surgery, University of Michigan, 1500 E Medical Ctr Dr, Taubman Center SPC5331, Ann Arbor, MI, 48109-5331, USA. calistah@med.umich.edu.ORCID https://orcid.org/0000-0001-7269-0088
Deepa ChandhrasekharDepartment of General Surgery, Virginia Mason Franciscan Health, Seattle, WA, USA.
Evan MongeDepartment of Surgery, University of Michigan, 1500 E Medical Ctr Dr, Taubman Center SPC5331, Ann Arbor, MI, 48109-5331, USA.
Emily HallerTrinity Health Ann Arbor, Ypsilanti, MI, USA.
Kelli GibbsDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Amanda LynettDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Scott RegenbogenDepartment of Surgery, University of Michigan, 1500 E Medical Ctr Dr, Taubman Center SPC5331, Ann Arbor, MI, 48109-5331, USA.
Michael RiceDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Samantha HendrenDepartment of Surgery, Indiana University, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExcessive fluid loss from a high-output ileostomy can lead to dehydration, electrolyte abnormalities, acute kidney injury, and readmissions. Yet, few guidelines exist to standardize management of this common complication. This narrative review aimed to systematically summarize the current literature on the evaluation, prevention, and treatment of high ileostomy output.

methodsPubMed and Cochrane Library were searched using keyword and MeSH search terms. Studies were included if they were relevant to (1) adult patients with a new or existing ileostomy and (2) high ileostomy output. Articles which addressed dehydration and/or acute kidney injury after ileostomy creation were also included as surrogates for high ileostomy output. One hundred twenty-nine articles met eligibility criteria for consideration for inclusion in the final review.

resultsA high-output ileostomy was reported in 16% of patients after ileostomy creation. The most common complications reported included dehydration (9-39% readmission rate) and acute kidney injury (33% readmission rate), with risk of progression to chronic kidney disease. Treatments included dietary interventions such as restricting hypotonic fluids and using an oral rehydration solution; pharmacologic therapies to reduce motility and gastrointestinal secretions; and perioperative pathways with standardized patient education.

conclusionEvidence-based protocols for prevention and treatment of HOI may decrease rates of dehydration, AKI, and readmission after ileostomy creation. The limitations of this review are the lack of randomized controlled or high-quality data and variation in the definition of outcomes.

Indexed as

Acute kidney injuryDehydrationIleostomyPathway

Identifiers

PMID42742826

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.