Evidence map›Paper›PMID 42742800›Full record

ArticleEuropean radiology experimental2026

Disrupted thalamic functional hierarchy on resting-state fMRI in idiopathic generalized epilepsy.

Junxia Chen, Xueqing Sun, Kai Yu, Zhihuan Yang, Hechun Li, Zeling Yang, Yuecong Chen, Jianfu Li, Roberto Rodriguez-Labrada, Dezhong Yao and 2 more

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In one paragraph

Article in European radiology experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Junxia ChenThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Xueqing SunThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Kai YuThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Zhihuan YangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Hechun LiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Zeling YangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Yuecong ChenThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Jianfu LiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Roberto Rodriguez-LabradaCuban Neuroscience Center, La Habana, Cuba.
Dezhong YaoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Sisi JiangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China.
Cheng LuoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, P. R. China. chengluo@uestc.edu.cn.ORCID http://orcid.org/0000-0003-0524-5886

Funding

National Key R&D Program of China 2024YFE0215100
6 · The paper itself

Abstract

objectiveAbnormal thalamo-cerebral and thalamo-cerebellar interactions are implicated in idiopathic generalized epilepsy (IGE), but their influence on thalamic functional hierarchy remains unclear. This study aimed to characterize thalamic functional hierarchy across varying connectivity strengths in IGE. MATERIALS AND

methodsResting-state functional magnetic resonance imaging (fMRI) data were collected for 144 IGE patients and 222 healthy controls. The voxel-wise thalamo-cerebral and thalamo-cerebellar functional connectivity (FC) was first computed. Connectome gradient mapping was applied separately to anticorrelated and correlated connectivity strengths for both thalamo-cerebral and thalamo-cerebellar pathways. Furthermore, the first three thalamic gradient features were investigated using eccentricity.

resultsIn both healthy controls and patients with IGE, the thalamus predominantly coupled with low-order unimodal networks under anticorrelated conditions, and with high-order cognitive networks under correlated conditions. Moreover, connectome-dependent alterations were further observed in the limbic network, attentional network, and cerebellar systems in IGE. Additionally, thalamic gradients in IGE showed marked distributional abnormalities across a broad range of connectivity strengths. Notably, both thalamo-cerebral and thalamo-cerebellar eccentricity revealed shared increases and decreases within motor and cognitive thalamic nuclei, together with additional pathway-specific abnormalities unique to the thalamo-cerebellar system. These dispersion abnormalities were associated with poorer working memory performance in IGE, with three significant thalamic clusters identified (all p ≤ 0.008).

conclusionThese fMRI findings demonstrate disruption of the thalamic functional hierarchy, manifested as nucleus-specific alterations in integration and segregation in IGE. Collectively, this study provides novel insights into thalamic functional abnormalities in epilepsy. KEY POINTS: Question The hierarchical disruption of thalamo-cerebral and thalamo-cerebellar pathways in idiopathic generalized epilepsy and its clinical significance remains unclear. Findings Both pathways show altered functional hierarchy, with eccentricity changes in specific thalamic nuclei linked to slower working memory performance in idiopathic generalized epilepsy. Relevance statement This study revealed nucleus-specific integration-segregation disruptions in IGE that correlated with poorer working memory performance, providing an important window into thalamic dysfunction mechanisms.

Indexed as

Epilepsy, GeneralizedMagnetic Resonance ImagingThalamusAdolescentAdultCase-Control StudiesConnectomeFemaleHumansMaleYoung AdultConnectomeEpilepsyFunctional neuroimagingMagnetic resonance imagingThalamus

Identifiers

PMID42742800
PMCPMC13578145

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