ArticleArchives of microbiology2026
Screening and identification of B-cell epitopes on the gH protein of varicella-zoster virus.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Varicella and herpes zoster are two clinically distinct diseases caused by varicella-zoster virus (VZV). The VZV envelope is enriched with multiple glycoproteins, among which glycoprotein H (gH) is a key envelope glycoprotein essential for viral entry into host cells and an important target of neutralizing antibodies. However, precise mapping of key protective epitopes on the gH protein remains incomplete. VZV gL functions as a molecular chaperone for gH and promotes its proper expression. In this study, the extracellular-domain sequence of gH and the full-length sequence of gL were co-cloned into the pCGS3 vector, and the VZV gH/gL heterodimer with native conformation was successfully expressed using a eukaryotic expression system. Using this heterodimer as the immunogen, five monoclonal antibodies (mAbs) specifically recognizing gH were obtained. Through overlapping peptide truncation assays, the linear B-cell epitopes targeted by these five mAbs were mapped to two regions of the gH protein:
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