ArticleCNS neuroscience & therapeutics2026
Frequency and Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Accompanied by Fever: A Single-Center Retrospective Study.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsTo evaluate the frequency and characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) accompanied by fever.
methodsThis retrospective study was conducted from April 2019 to December 2025 at Beijing Tiantan Hospital in China. Patients who met the 2023 international MOGAD panel diagnostic criteria and had a disease duration of at least 6 months were included. Febrile and afebrile groups were compared using Mann-Whitney U, χ
resultsA total of 123 patients were included. Fever occurred during 43 acute attacks in 38 (30.9%) patients, with the majority (33 attacks) representing the initial episode. The median maximal temperature was 38.6°C. Cerebral cortical encephalitis was the leading phenotype in febrile attacks (48.8%). Compared to the afebrile group, the febrile group exhibited a significantly higher median cerebrospinal fluid (CSF) leukocyte count (56/μL vs. 11.5/μL; p < 0.001) and CSF protein (52.65 mg/dL vs. 39.76 mg/dL; p = 0.001). Cerebral cortical encephalitis and CSF pleocytosis were independently associated with fever in the multivariable model.
conclusionsFever was relatively common in our MOGAD cohort, occurring in approximately one-third of patients and across all clinical phenotypes. Both cerebral cortical encephalitis and CSF pleocytosis were independently associated with fever.
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