Evidence map›Paper›PMID 42742377›Full record

ArticleAnalytical cellular pathology (Amsterdam)2026

CCND1 Stability Regulated by USP7 Deubiquitination Controls Glioma Radioresistance via Ferroptosis.

Yayu Zhuo, Chenrui Zhang, Xiaoyu Li, Zishuo Du, Yiren Rong, Di Zhang, Haijuan Mi, Xiaoyu Gu, Feng Wang, Haie Han and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yayu ZhuoDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0005-5863-7914
Chenrui ZhangDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0005-5820-9530
Xiaoyu LiDepartment of Thyroid and Breast Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0005-0385-9202
Zishuo DuThe Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0007-5176-1423
Yiren RongThe Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0004-1246-722X
Di ZhangShenze County People's Hospital, Shijiazhuang 050000, Hebei, China.ORCID https://orcid.org/0009-0005-3207-1123
Haijuan MiXingtang County Chinese Medicine Hospital, Shijiazhuang 050000, Hebei, China.ORCID https://orcid.org/0009-0005-3232-6982
Xiaoyu GuDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0008-9334-0026
Feng WangDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0000-0002-8084-2464
Haie HanDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0004-6552-1592
Jianliang WuDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0004-9351-4285
Jianping SunDepartment of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China, hebmu.edu.cn.ORCID https://orcid.org/0000-0003-1089-3255

Funding

Hebei Provincial Health Commission Medical Research Project 20211355Natural Science Foundation of Hebei Province H202520660
6 · The paper itself

Abstract

Dysregulation of Cyclin D1 (CCND1) is implicated in various cancers, but its specific contribution to glioma radioresistance and the associated regulatory mechanisms remain largely unexplored. This research aimed to elucidate the functional role and underlying mechanisms of CCND1 in glioma radioresistance. Our findings revealed that CCND1 is significantly upregulated in glioma tissues, which correlates with a poor prognosis. Furthermore, CCND1 knockdown inhibited proliferation, triggered apoptosis, and augmented radiosensitivity in glioma cells. Additionally, CCND1 depletion sensitized glioma cells to irradiation by driving ferroptosis, as indicated by elevated reactive oxygen species (ROS) production, lipid peroxidation, and intracellular Fe

Indexed as

Brain NeoplasmsCyclin D1FerroptosisGliomaRadiation ToleranceUbiquitinationUbiquitin-Specific Peptidase 7ApoptosisCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansProtein StabilityReactive Oxygen SpeciesCCND1 protein, humanCyclin D1Reactive Oxygen SpeciesUbiquitin-Specific Peptidase 7USP7 protein, humanCCND1ferroptosisgliomaradioresistanceUSP7

Identifiers

PMID42742377
PMCPMC13576636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.