Evidence map›Paper›PMID 42742219›Full record

Observational studyMicrobiology spectrum2026

Longitudinal and adjusted prognostic assessment of calprotectin in Gram-negative sepsis with acute respiratory failure.

Simona Gigliotti, Michele Manno, Manuela Colosimo, Francesca Divenuto, Francesco Dragone, Marta Greco, Cinzia Peronace, Luigia Gallo, Francesca Trimboli, Pasquale Minchella and 7 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Simona GigliottiClinical Microbiology Unit, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
Michele MannoClinical Microbiology Unit, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
Manuela ColosimoMicrobiology and Virology Unit, R. Dulbecco University Hospital, Catanzaro, Italy.
Francesca DivenutoClinical Microbiology Unit, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
Francesco DragoneClinical Pathology Unit, Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy.
Marta GrecoClinical Pathology Unit, Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy.
Cinzia PeronaceClinical Microbiology Unit, Renato Dulbecco University Hospital, Catanzaro, Italy.
Luigia GalloClinical Microbiology Unit, Renato Dulbecco University Hospital, Catanzaro, Italy.
Francesca TrimboliClinical Microbiology Unit, Renato Dulbecco University Hospital, Catanzaro, Italy.
Pasquale MinchellaMicrobiology and Virology Unit, R. Dulbecco University Hospital, Catanzaro, Italy.
Francesca GrecoMicrobiology Unit, Annunziata Hub Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy.
Alba SilipoDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Nadia MarascioClinical Microbiology Unit, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
Eugenio GarofaloAnesthesia and Intensive Care, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Federico LonghiniAnesthesia and Intensive Care, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.ORCID 0000-0002-6970-7202
Angela QuirinoClinical Microbiology Unit, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.
Giovanni MateraClinical Microbiology Unit, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.

Funding

Ministero dell'Università e della Ricerca PRIN PNRR 2022 (Prot P2022M457Z)
6 · The paper itself

Abstract

Sepsis caused by Gram-negative bloodstream infection is characterized by dynamic host responses, but the longitudinal and incremental prognostic value of calprotectin remains uncertain. We conducted a multicenter retrospective observational study of 82 adults with Gram-negative bloodstream infection, sepsis, and acute respiratory failure. Serum calprotectin, routine biomarkers, cytokines, and growth factors were measured at diagnosis before antibiotic therapy (T0), day 3 (T1), and day 7 (T2), and compared according to 28-day survival. Sixty-four patients survived, and 18 died. Calprotectin declined over time but remained higher in non-survivors at T0 (

Indexed as

Gram-Negative Bacterial InfectionsLeukocyte L1 Antigen ComplexRespiratory InsufficiencySepsisAgedBiomarkersFemaleHumansLongitudinal StudiesMaleMiddle AgedPrognosisRetrospective StudiesBiomarkersLeukocyte L1 Antigen Complexbiomarkerscalprotectincytokinesinflammationmortalitysepsis

Identifiers

PMID42742219
PMCPMC13689393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.