ArticleMicrobiology spectrum2026
TRPV1-STAT3 signaling as a driver of lethal pathology during pneumococcal nose-to-brain invasion.
Hideki Sakatani, Ryo Ueda, Masamitsu Kono, Taku Fujishiro, Masayoshi Hijiya, Yohei Morita, Kohei Kawabata, Takuma Okada, Kazuya Mizobata, Shizuya Saika and 1 more
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In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Hideki Sakatani *Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.ORCID 0009-0003-1995-9174 Ryo Ueda *Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Masamitsu Kono *Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.ORCID 0000-0002-7896-4892 Taku FujishiroDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Masayoshi HijiyaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Yohei MoritaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Kohei KawabataDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Takuma OkadaDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Kazuya MizobataDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Shizuya SaikaDepartment of Ophthalmology, Wakayama Medical University, Wakayama, Japan.
Muneki HotomiDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.ORCID 0000-0003-4705-5319 Funding
Japan Society for the Promotion of Science 25K02792Japan Society for the Promotion of Science 25K12748Japan Society for the Promotion of Science 25K12771Japan Society for the Promotion of Science 26K12463
6 · The paper itselfAbstract
Nose-to-brain infection represents a non-hematogenous route by which pathogens invade the central nervous system via neural pathways. The olfactory and trigeminal systems are implicated in this process, but the molecular mechanisms underlying lethal pathology remain incompletely understood. We hypothesized that trigeminal TRPV1 and downstream STAT3 signaling contribute to disease progression during pneumococcal nose-to-brain infection. A murine intranasal infection model using
Indexed as
Pneumococcal InfectionsSTAT3 Transcription FactorStreptococcus pneumoniaeTRPV Cation ChannelsAnimalsBrainDisease Models, AnimalFemaleMiceMice, Inbred C57BLOlfactory BulbSignal TransductionStat3 protein, mouseSTAT3 Transcription FactorTRPV1 protein, mouseTRPV Cation Channelsinvasive pneumococcal diseasessignal transducer and activator of transcription 3spatial transcriptomeStreptococcus pneumoniaetransient receptor potential vanilloid 1
Identifiers
PMID42742208
PMCPMC13689226
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