Evidence map›Paper›PMID 42742198›Full record

ArticleActa crystallographica. Section F, Structural biology communications2026

Crystal structures of the sweet-tasting protein honey truffle active component from Mattirolomyces terfezioides.

Tyler T Pitkanen, Anne Cooper, Phillip Vo, Chase T McFarland, Ranjan Patnaik, Scott Lovell, Daniel E Connors

Abstract read
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In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tyler T PitkanenMycoTechnology, Inc., 18250 East 40th Avenue, Aurora, CO 80011, USA.ORCID 0000-0001-5058-5631
Anne CooperProtein Structure and X-ray Crystallography Laboratory, University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0002-1893-4149
Phillip VoMycoTechnology, Inc., 18250 East 40th Avenue, Aurora, CO 80011, USA.ORCID 0009-0007-4591-3048
Chase T McFarlandMycoTechnology, Inc., 18250 East 40th Avenue, Aurora, CO 80011, USA.
Ranjan PatnaikMycoTechnology, Inc., 18250 East 40th Avenue, Aurora, CO 80011, USA.ORCID 0009-0000-2112-051X
Scott LovellProtein Structure and X-ray Crystallography Laboratory, University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0002-3215-4472
Daniel E ConnorsMycoTechnology, Inc., 18250 East 40th Avenue, Aurora, CO 80011, USA.ORCID 0009-0006-7930-5107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crystal structures of honey truffle active component (HT-AC) originally derived from the fungus Mattirolomyces terfezioides are reported for the first time. HT-AC is a 13 kDa protein and is one of a small class of unrelated proteins that interact with an allosteric site on the human T1R2/R3 sweet taste receptor. These proteins can be used as sweeteners, and result in sweet taste perception at lower concentrations than sugar (the orthosteric receptor target) or many other high-intensity small-molecule sweeteners. Orthorhombic (space group P2

Indexed as

AscomycotaFungal ProteinsHoneyReceptors, G-Protein-CoupledSweetening AgentsAmino Acid SequenceCrystallizationCrystallography, X-RayHumansModels, MolecularFungal ProteinsReceptors, G-Protein-CoupledSweetening Agentstaste receptors, type 1honey truffle active componentMattirolomyces terfezioidessweet proteins

Identifiers

PMID42742198
PMCPMC13629642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.