Evidence map›Paper›PMID 42742194›Full record

ReviewJournal of comparative effectiveness research2026

Bridging the divide between health economics and outcomes research and biomedical investment: reflections from a health economist working in venture capital.

Richard Z Xie

Abstract readReview
In one paragraph

Review in Journal of comparative effectiveness research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Richard Z XieRA Capital Management, 200 Berkeley St, 18th Floor, Boston, MA 02116, USA.ORCID 0000-0002-2797-3019

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite investors' pivotal role in shaping biomedical innovation, interaction between the investment community and health economics and outcomes research professionals remains limited. Both communities seek to understand what society values and how to allocate resources accordingly, yet these conversations occur largely in parallel. This perspective article, written from the viewpoint of a health economist who joined a major biomedical investment firm, seeks to bridge that divide. Drawing on first-hand observations across three domains - profits, incentives and societal value; coverage, pricing and patient access; and public policy and innovation - it argues that health economics and outcomes research must reconnect with its economic foundations, incorporate insights from real-world investment practice, and update its methods to better inform policy, promote innovation and improve patient welfare in a market-based system.

Indexed as

Economics, MedicalInvestmentsOutcome Assessment, Health CareCost-Benefit AnalysisHumansdrug pricinggeneralized cost-effectiveness analysishealth economicshealth technology assessmentInflation Reduction Actinvestment decision-makingmarket accessMost-Favored-Nationpharmaceutical innovationvalue assessment

Identifiers

PMID42742194
PMCPMC13648045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.