Evidence map›Paper›PMID 42742174›Full record

ArticleNature2026

Highly efficient base editing at PCSK9 and normal human embryo development.

Stepan Jerabek, Chanju Jung, Michelle Kappy, Qiaojin Zhao, Julie Sung, Ning Wang, Euihyun Kim, Jimin Kim, Marcos Iuri Roos Kulmann, Madeleine Bliss King and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Stepan JerabekColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.
Chanju JungDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Michelle KappyDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
Qiaojin ZhaoColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.ORCID http://orcid.org/0009-0008-8975-2597
Julie SungColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.
Ning WangColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.
Euihyun KimColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.
Jimin KimColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.
Marcos Iuri Roos KulmannInstitute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Madeleine Bliss KingSchool of Molecular Sciences, Arizona State University, Tempe, AZ, USA.ORCID http://orcid.org/0000-0003-1245-8126
Mitchell John McAndrewGavin Herbert Eye Institute, Brunson Center for Translational Vision Research, Department of Ophthalmology & Visual Science, University of California Irvine, School of Medicine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-6402-8182
Meng LiDepartment of Medicine, Columbia University, New York, NY, USA.
Sakshi BhateleColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.ORCID http://orcid.org/0000-0002-2514-193X
Melisa IsadoColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.
Hong-Su JangDepartment of Life Sciences, Korea University, Seoul, Republic of Korea.
Michal DolezalInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-8814-7805
Robert ProsserDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
Shuangyi XuColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA.
Gue-Ho HwangMedical Research Center of Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Iva PichovaInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-2178-9819
Jia XuGenomic Prediction, Hackettstown, NJ, USA.ORCID http://orcid.org/0000-0003-3921-018X
Diego MarinGenomic Prediction, Hackettstown, NJ, USA.
Jae-Sung WooCenter for Biomolecular and Cellular Structure, Institute for Basic Science, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0001-9163-3433
Sangsu BaeDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-3615-8566
Nathan TreffGenomic Prediction, Hackettstown, NJ, USA.
Audrone LapinaiteGavin Herbert Eye Institute, Brunson Center for Translational Vision Research, Department of Ophthalmology & Visual Science, University of California Irvine, School of Medicine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-9427-9342
Dieter EgliColumbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY, USA. de2220@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-0812-6412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cas9-based tools enable programmable DNA lesions for studying repair outcomes, gene function and genome correction. In human embryos, Cas9-induced DNA double-stranded breaks are genotoxic, causing frequent aneuploidy and large deletions

Identifiers

PMID42742174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.