Evidence map›Paper›PMID 42742172›Full record

ArticleNature2026

Dialkyl ether synthesis through heteroatom homolytic substitution.

Johannes J Großkopf, Johnny Z Wang, Jacqueline W Gu, Cheng Bi, Sarah N Dishman, Xiaoshen Ma, Yu-Hong Lam, David W C MacMillan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Johannes J Großkopf *Merck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-6540-3893
Johnny Z Wang *Merck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-5021-681X
Jacqueline W GuMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0009-0009-1070-673X
Cheng BiDepartment of Process Research & Development, Merck & Co, Inc., Boston, MA, USA.
Sarah N DishmanDepartment of Discovery Chemistry, Merck & Co, Inc., Boston, MA, USA.
Xiaoshen MaDepartment of Discovery Chemistry, Merck & Co, Inc., Boston, MA, USA.ORCID http://orcid.org/0000-0002-0713-2896
Yu-Hong LamDepartment of Modeling & Informatics, Merck & Co, Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0002-4946-1487
David W C MacMillanMerck Center for Catalysis at Princeton University, Princeton, NJ, USA. dmacmill@princeton.edu.ORCID http://orcid.org/0000-0001-6447-0587

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modular and selective synthesis of dialkyl ethers, particularly sterically congested variants, remains a longstanding challenge in drug discovery and medicinal chemistry

Identifiers

PMID42742172
PMCPMC13626950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.