Evidence map›Paper›PMID 42742168›Full record

ArticleNature2026

Phosphine-mediated azine C-H couplings with water and ammonia.

Kyle G Nottingham, Dane A Brunner, David Dalmau, Amanda K Melanese, Juan V Alegre-Requena, Robert S Paton, Andrew McNally

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kyle G NottinghamDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA.
Dane A BrunnerDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA.
David DalmauDepartamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, Zaragoza, Spain.
Amanda K MelaneseDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0003-0821-2895
Juan V Alegre-RequenaDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA. jv.alegre@csic.es.ORCID http://orcid.org/0000-0002-0769-7168
Robert S PatonDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA. Robert.Paton@colostate.edu.ORCID http://orcid.org/0000-0002-0104-4166
Andrew McNallyDepartment of Chemistry, Colorado State University, Fort Collins, CO, USA. Andy.McNally@colostate.edu.ORCID http://orcid.org/0000-0002-8651-1631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unique reactivity of transition metals has advanced C-H functionalization chemistry, enabling practitioners to directly modify drug and agrochemical compounds during structure-activity relationship (SAR) studies. These metals are particularly adept at transforming the C-H bonds of arenes and aromatic heterocycles, generating new reactions that form C-C and C-heteroatom bonds. However, among the many potential coupling partners, (hetero)arene C-H coupling reactions with water and ammonia are rare

Identifiers

PMID42742168
PMCPMC13600945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.