Evidence map›Paper›PMID 42742125›Full record

ArticleThe oncologist2026

Real-world use of tafasitamab for relapsed or refractory diffuse large B-cell lymphoma among racial and ethnic minorities in the United States.

Narendranath Epperla, Loretta J Nastoupil, Bruce Feinberg, John Galvin, Prathamesh Pathak, Theresa Amoloja, Danielle Gentile, Parisa Asgarisabet, Kim Saverno

Abstract read
In one paragraph

Article in The oncologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Narendranath EpperlaDivision of Hematology, The Ohio State University, Columbus, OH 43201, United States.
Loretta J NastoupilDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
Bruce FeinbergCardinal Health, Dublin, OH 43017, United States.
John GalvinIncyte Corporation, Wilmington, DE 19803, United States.
Prathamesh PathakCardinal Health, Dublin, OH 43017, United States.ORCID 0009-0001-8499-3059
Theresa AmolojaIncyte Corporation, Wilmington, DE 19803, United States.
Danielle GentileCardinal Health, Dublin, OH 43017, United States.ORCID 0000-0001-8516-9881
Parisa AsgarisabetCardinal Health, Dublin, OH 43017, United States.
Kim SavernoIncyte Corporation, Wilmington, DE 19803, United States.ORCID 0000-0002-3421-3755

Funding

Cardinal Health
6 · The paper itself

Abstract

backgroundOutcomes may differ among patients with diffuse large B-cell lymphoma (DLBCL) based on race and ethnicity; however, individuals from diverse racial and ethnic backgrounds have historically been underrepresented in clinical trials. This study describes the real-world characteristics, treatment patterns, and outcomes of patients treated with tafasitamab, an anti-CD19 monoclonal antibody for relapsed or refractory (R/R) DLBCL, by race and ethnicity.

methodsA descriptive subgroup analysis by race and ethnicity was conducted from a retrospective, physician-abstracted medical chart review study. Patients were aged ≥18 years, initiated tafasitamab treatment for R/R DLBCL on/after October 21, 2020, and had ≥4 months follow-up; patients who died during follow-up were included. Data were collected from February 22 to March 29, 2023, and from December 18, 2023 to January 31, 2024.

resultsThe analysis included 181 patients: 64.1% White, 22.1% Black or African American, 7.7% Other (race other than White, Black or African American, or unknown), 6.1% were of unknown race; 82.3% non-Hispanic, 17.1% Hispanic, and 0.6% were of unknown ethnicity. The median (Q1-Q3) follow-up time for the overall study population from tafasitamab initiation was 14.7 (8.5-17.1) months and was relatively similar for all subgroups. Most patients (71.8%) received tafasitamab in second-line and this was true across subgroups. Real-world overall response rates (95% CI) were 73.3% (65.2-81.3), 82.5% (70.7-94.3), 74.5% (67.5-81.5), and 67.7% (51.3-84.2) for White, Black or African American, non-Hispanic, and Hispanic patients, respectively.

conclusionsFindings suggest effectiveness outcomes among patients receiving tafasitamab for R/R DLBCL were consistent across racial and ethnic groups.

Indexed as

Antibodies, Monoclonal, HumanizedEthnic and Racial MinoritiesLymphoma, Large B-Cell, DiffuseNeoplasm Recurrence, LocalAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesUnited StatesWhiteAntibodies, Monoclonal, Humanizedtafasitamabdiffuse large B-cell lymphomaethnicityimmunotherapyrace

Identifiers

PMID42742125
PMCPMC13623528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.