Evidence map›Paper›PMID 42741991›Full record

SynthesisChemistry & biodiversity2026

Endophytic Fungi Natural Factories of Novel Bioactive Compounds.

Dilmurod Murodullayev, Jakhongir Movlanov, Liu Wei, Wei Liu, Maksud Isokov, Santosh Kumar Bose, Fazliddin Kobilov, Zamira Djumayeva, Buston Islamov, Jamila Sherkulova and 9 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Dilmurod MurodullayevInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Jakhongir MovlanovUniversity of Geological Science, Center of Geoinnovation Technologies, Tashkent, Uzbekistan.ORCID https://orcid.org/0000-0001-8850-1157
Liu WeiQilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Jinan, Shandong, China.
Wei LiuQilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Jinan, Shandong, China.
Maksud IsokovUniversity of Geological Science, Center of Geoinnovation Technologies, Tashkent, Uzbekistan.
Santosh Kumar BoseDepartment of Horticulture Patuakhali Science and Technology University, Dumki, Patuakhali, Bangladesh.ORCID https://orcid.org/0000-0003-1987-1765
Fazliddin KobilovInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.ORCID https://orcid.org/0009-0006-0881-0827
Zamira DjumayevaSamarkand State Pedagogical Institute, Samarkand, Uzbekistan.
Buston IslamovInstitute of Biochemistry, Samarkand State University, University Boulevard 15, Samarkand, Uzbekistan.
Jamila SherkulovaKarshi State University, Karshi district, Uzbekistan.ORCID https://orcid.org/0000-0003-0588-9614
Zafar MatyakubovKhorezm Mamun Academy, Khiva city, Khorezm, Uzbekistan.ORCID https://orcid.org/0000-0003-0404-7589
Muniskhon MeylievaInstitute of Hydrogeology and Engineering Geology, University of Geological Science, Tashkent, Uzbekistan.
Munisa ErgashevaSamarkand State Medical University, Samarkand, Uzbekistan.
Diyor AbduraxmanovSamarkand State Medical University, Samarkand, Uzbekistan.ORCID https://orcid.org/0000-0003-4982-568X
Guozheng HuangDepartment of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui, China.
Hongchen JiangSchool of Life Sciences, Henan University, Kaifeng, China.
Kakhramon DavranovInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Guohui PanState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-8839-3886
Nigora RustamovaInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.ORCID https://orcid.org/0000-0002-5731-9819

Funding

Discovery of bio control
6 · The paper itself

Abstract

Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological potential. This systematic review examines 118 studies published between 2024 and 2025, reporting the discovery of 242 previously uncharacterized bioactive compounds. These metabolites belong to several major chemical classes, including peptides (4), terpenoids and steroids (58), alkaloids and other nitrogen-containing compounds (51), polyketides (85), lactones (22), ketones (5), chromone compounds (3), and others (9). The genera Aspergillus (28), Penicillium (21), Diaporthe (7), Talaromyces (10), and Trichoderma (6) were identified as the most productive sources. The investigated endophytic fungi were isolated from a wide range of plant hosts and ecological niches, reflecting the extensive biodiversity of endophytic communities. Biological screening demonstrated that a substantial proportion of the tested compounds exhibited diverse bioactivities, including anti-inflammatory, antibacterial, antifungal, antimicroalgal, and cytotoxic effects. Collectively, the remarkable structural diversity and broad biological profiles of metabolites derived from endophytic fungi highlight their strong potential as promising lead scaffolds for future pharmaceutical development.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBiological ProductsEndophytesFungiAnimalsAnti-Inflammatory AgentsAntineoplastic AgentsHumansAnti-Bacterial AgentsAntifungal AgentsAnti-Inflammatory AgentsAntineoplastic AgentsBiological Productsbiological activityendophytic microorganismnatural productspecialized metabolites

Identifiers

PMID42741991
PMCPMC13575952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.