ArticleLiver international : official journal of the International Association for the Study of the Liver2026
Incidence and Mortality of Community-Acquired Sepsis or Bacteraemia in Patients With Alcohol-Related Cirrhosis.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Incidence and Mortality of Community-Acquired Sepsis or Bacteraemia in Patients With Alcohol-Related Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsLiver cirrhosis is associated with an increased risk of bacterial infections, but there is a lack of reliable population-based data to quantify this risk. We examined the incidence and predictors of community-acquired serious systemic infections.
methodsThis was a population-based study that included all patients in the Central Denmark Region diagnosed with alcohol-related cirrhosis (ALD cirrhosis) in 2013-2022. We computed the cumulative incidence of community-acquired serious systemic infections, encompassing sepsis and bacteraemia. We used Fine & Gray regression to investigate predictors of infection within the first year.
resultsWe included 2511 patients with ALD cirrhosis (69.3% males, median age 61 years, median MELD-NA score 13). Their cumulative risk of a first-time community-acquired serious systemic infection was 3.8% (95% CI: 3.1-4.6) after 1 year and 5.9% (95% CI: 5.0-6.9) after 3 years. The most frequent causative pathogens were Enterobacterales (38%), Staphylococci (25%) and Streptococci (22%). Increasing MELD-Na score at cirrhosis diagnosis was associated with an increased risk of serious systemic infection within the first year after diagnosis (subdistribution hazard ratio = 1.05, 95% CI: 1.02-1.08, per 1 point increase). The 30-day all-cause mortality was 30% (95% CI: 23-37) following hospitalization with a serious systemic infection.
conclusionsThis population-based study determined the risk and mortality of serious systemic infections in ALD cirrhosis. Our findings will be important for future studies of interventions to prevent infections.
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