ArticlePlastic and reconstructive surgery. Global open2026
Epigenetic Mechanisms in Cleft Lip and Palate: A Comprehensive Review of Current Insights and Future Perspectives.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cleft lip and palate (CL/P), the most common craniofacial birth defect, affects approximately 1 in 500 live births in China. CL/P severely compromises facial aesthetics, physiological functions (eg, feeding, speech), and imposes significant psychological and economic burdens on patients and families. Genetic and environmental factors are known to contribute, but recent studies have added another layer: epigenetic dysregulation. This review summarizes recent advances in understanding epigenetic modifications-including DNA methylation, noncoding RNAs, histone modifications, and X-chromosome inactivation-in CL/P development. We discuss how these mechanisms interact with genetic and environmental factors to disrupt craniofacial morphogenesis, providing novel insights into diagnostic biomarkers and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.