ArticleSensors and actuators. B, Chemical2026
Mechanistic Insights of miRNA Hybridization with ssDNA Self Assembled Monolayers on Gold Electrodes: An Electrochemical and Computational Study.
Article in Sensors and actuators. B, Chemical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This work studies the hybridization dynamics of microRNAs with surface-immobilized complementary ssDNA probes. The ssDNA with a terminal thiol group was designed to allow it to form a self-assembled monolayer (SAM) on a Au electrode with low density of coverage to promote flexible ssDNA surface conformations. We characterized the hybridization of immobilized ssDNA with miRNA-4484, a biomarker for various diseases via multiple electrochemical methods including voltammetry, impedance spectroscopy, and open circuit potential. Hybridization events are monitored via electrochemical readouts of the Methylene Blue (MB) labeled ssDNA. For ssDNA without a MB label, an external redox probe, namely Fe(CN)
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